ALLHAT

Also found in: Acronyms.

Antihypertensive & Lipid Lowering Treatment to Prevent Heart Attack Trial. An ongoing trial evaluating whether antihypertensive therapy decreases morbidity and mortality in CAD, and whether lipid-lowering in moderately hypercholestaeremic patients decreases cardiovascular morbidity and mortality
Conclusion No major differences for antihypertensives and lipid-lowering agents in fatal CHD or nonfatal MIs

ALLHAT

Cardiology An ongoing randomized, open label, multicenter trial evaluating whether antihypertensive therapy reduces M&M in CAD, and to determine whether lipid-lowering pravastatin therapy in moderately hypercholesteremic Pts reduces heart-related M&M. See Antihypertensive, Hypertension, Pravastatin.

Mentioned in ?

trial

References in periodicals archive ?

The research team looked at a meta-analysis of the ALLHAT study and 28 other high blood pressure clinical studies in which patient data were combined and results compared, as well as new clinical trials including the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH).

Study confirms 'water pill' outperforms other high blood pressure drugs

"ALLHAT says these metabolic abnormalities did not translate into excess morbidity or mortality.

Hypertension study fails to end clinical debate; ALLHAT found increase in new-onset diabetes did not translate into higher risk of heart disease events

They acknowledged that a criticism of the previous ALLHAT findings was that the follow-up was too short for the metabolic benefits of the newer drugs to translate into reductions in the risk for the adverse events.

New hypertension drugs not necessarily the best

According to ALLHAT, diuretic use declined from 56% of antihypertensive medications in 1982 to 27% a decade later.

Hypertension study yields surprising results. (RX News)

Subsequent to ALLHAT, the benefits and safety of calcium antagonists vs a thiazide diuretic combined with an angiotensin-converting enzyme inhibitor (ACEI) were addressed by the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial.

Module 1: historical review of evidence-based treatment of hypertension

(11) Even 4 years after the ALLHAT results were published, national use of thiazide-type drugs had not increased significantly.

Module 2: rethinking the role of thiazide-type diuretics in the management of hypertension: which diuretic is best?

ALLHAT was the first outcome study to evaluate the relative benefit of antihypertensive treatment initiated with newer classes of antihypertensive agents vs treatment initiated with a THZD in blacks.

Module 3: using thiazide-type diuretics in African Americans with hypertension

Second, ALLHAT was designed to compare individual drugs, while ASCOT was designed to compare two forms of combination therapy, said Dr.

Fewer CV events seen with combo blood pressure Tx; amlodipine plus perindopril saved lives

In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), even though patients randomized to the calcium channel blocker amlodipine rather quickly lowered BP by 2-4 mm Hg, with lisinopril's RAS blockage, they got less heart failure and diabetes.

Should hypertension be treated with a renin-angiotensin blocker?

(29.) ALLHAT Officers and Coordinators, for the ALLHAT Collaborative Research Group.

Low-density lipoprotein cholesterol and coronary heart disease: the importance of reaching target goals with statin therapy

In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack (ALLHAT) trial, even though patients randomized to the calcium channel blocker amlodipine rather quickly lowered BP by 2-4 mm Hg, with lisinopril's RAS blockage, they got less heart failure and diabetes.

Should hypertension be treated with a renin-angiotensin blocker?

A Major Study Indicates Current Therapies Fail to Get Many Patients to BP Goal (ALLHAT) (3)