ALLHAT


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Antihypertensive & Lipid Lowering Treatment to Prevent Heart Attack Trial. An ongoing trial evaluating whether antihypertensive therapy decreases morbidity and mortality in CAD, and whether lipid-lowering in moderately hypercholestaeremic patients decreases cardiovascular morbidity and mortality
Conclusion No major differences for antihypertensives and lipid-lowering agents in fatal CHD or nonfatal MIs

ALLHAT

Cardiology An ongoing randomized, open label, multicenter trial evaluating whether antihypertensive therapy reduces M&M in CAD, and to determine whether lipid-lowering pravastatin therapy in moderately hypercholesteremic Pts reduces heart-related M&M. See Antihypertensive, Hypertension, Pravastatin.
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The research team looked at a meta-analysis of the ALLHAT study and 28 other high blood pressure clinical studies in which patient data were combined and results compared, as well as new clinical trials including the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH).
They acknowledged that a criticism of the previous ALLHAT findings was that the follow-up was too short for the metabolic benefits of the newer drugs to translate into reductions in the risk for the adverse events.
According to ALLHAT, diuretic use declined from 56% of antihypertensive medications in 1982 to 27% a decade later.
Subsequent to ALLHAT, the benefits and safety of calcium antagonists vs a thiazide diuretic combined with an angiotensin-converting enzyme inhibitor (ACEI) were addressed by the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial.
(11) Even 4 years after the ALLHAT results were published, national use of thiazide-type drugs had not increased significantly.
ALLHAT was the first outcome study to evaluate the relative benefit of antihypertensive treatment initiated with newer classes of antihypertensive agents vs treatment initiated with a THZD in blacks.
Second, ALLHAT was designed to compare individual drugs, while ASCOT was designed to compare two forms of combination therapy, said Dr.
In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), even though patients randomized to the calcium channel blocker amlodipine rather quickly lowered BP by 2-4 mm Hg, with lisinopril's RAS blockage, they got less heart failure and diabetes.
(29.) ALLHAT Officers and Coordinators, for the ALLHAT Collaborative Research Group.
In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack (ALLHAT) trial, even though patients randomized to the calcium channel blocker amlodipine rather quickly lowered BP by 2-4 mm Hg, with lisinopril's RAS blockage, they got less heart failure and diabetes.
A Major Study Indicates Current Therapies Fail to Get Many Patients to BP Goal (ALLHAT) (3)