BMPR1B

(redirected from ALK6)

BMPR1B

A gene on chromosome 4q23-q24 that encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases, which binds and activates SMAD transcriptional regulators. BMPR1A is a receptor for BMP7/OP-1 and GDF5.

Molecular pathology
BMPR1B mutations cause acromesomelic chondrodysplasia with genital anomalies, brachydactyly type A2, and are associated with primary pulmonary hypertension.
References in periodicals archive ?
The BMP15 paracrine factor uses a more classic way of signal transduction, joining to its BMPRII and ALK6 receptors and subsequently activating the Smads 1, 5, and 8 (Moore et al.