ALK


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ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
References in periodicals archive ?
In April 2017, lorlatinib received Breakthrough Therapy Designation from the FDA for patients with ALK-positive metastatic NSCLC previously treated with one or more ALK inhibitors.
Despite the merger with Virgin whose margins have historically lagged industry averages, ALK generated the highest EBIT margin among Fitch's rated North American peer group.
Today, testing for EGFR mutations and ALK rearrangements is standard of care in advanced-stage nonsquamous NSCLC, irrespective of clinicopathologic characteristics (eg, smoking history, age, sex, or adenocarcinoma morphology).
Anaplastic lymphoma kinase (ALK) protein is expressed by approximately 70% of ALCLs as a result of chromosomal abnormalities involving the ALK gene.
Several novel ALK inhibitors have been developed to conquer crizotinib resistance (mostly that mediated by the gatekeeper mutation).
Insight ALK Screen is inexpensive, highly sensitive and well suited to handle larger numbers of specimens than the ALK detection methods currently available.
GenASIs further adds the ability to perform “walk away” automated genetic tissue scanning for ALK using an 81 slide continues scanning robot.
The study assessed crizotinib in 76 patients with NSCLC and ALK gene fusion.
This agreement gives ALK access to Tele Atlas' global digital map content and products, including content for over 24 million points of interest (POIs) and additional map enhancement products.
ALK translocation-positive patient samples included 5 cases collected from Brigham and Women's Hospital (Boston, Massachusetts), 4 collected from Florida Hospital (Orlando, Florida), 2 collected from Highland Park NorthShore University Hospital (Highland Park, Illinois), 1 collected from Northwestern Memorial Hospital (Chicago, Illinois), and 5 collected from Houston Methodist Hospital (Houston, Texas).
Premarket approval of the VENTANA ALK (D5F3) CDx Assay will enable more lung cancer patients to access ALK gene testing and obtain faster test results over current FISH or molecular testing methods.
ALK Technologies brings you the Technology That Drives Transportation[TM].