ALK


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ALK

Abbreviation for:
activin-like kinase
anaplastic lymphoma kinase, see there

Genetics
A gene on 2p23 that encodes an orphan receptor with tyrosine kinase activity belonging to the insulin receptor superfamily, which plays an important role in brain development.

Molecular pathology
ALK is amplified, mutated and rearranged in various cancers, including anaplastic large cell lymphomas, neuroblastoma and non-small cell lung cancer. The most common genetic alterations seen in ALK malfunction are chromosomal rearrangements resulting in multiple fusion genes, including ALK/EML4, ALK/RANBP2 and ALK/ATIC (all on chromosome 2); ALK/TFG (on chromosome 3); ALK/NPM1 and ALK/SQSTM1 (both on chromosome 5); ALK/KIF5B (on chromosome 10); ALK/CLTC (on chromosome 17); ALK/TPM4 (on chromosome 19); and ALK/MSN (on X chromosome).
References in periodicals archive ?
According to ALK, it has been targeting an entry into this important US market segment for a number of years.
The conditional marketing authorisation was based on results from a non-randomised, dose-ranging and activity-estimating, multi-cohort, multi-centre Phase 1/2 study, B7461001, assessing the product for the treatment of patients with ALK-positive advanced NSCLC, who were previously treated with one or more ALK TKIs.
ALK yeniden duzenlenmesini (EML4-ALK) saptamak icin uygun prob ve kitlerle FISH testi calisilmis ve BX51 floresan mikroskobuyla (Olympus BX51) analiz edilmistir.
IMTs commonly harbor chromosomal rearrangements resulting in fusions of the 3' kinase-containing portion of ALK to the 5' portion of a constitutively expressed gene, resulting in activation of the kinase domain and abnormal expression of ALK protein.
Fitch's primary rating concerns center around ALK's higher debt levels and the integration of the two airlines as previous acquisitions in the industry have led to years of operational issues.
Despite the diagnosis of SCC, the patient underwent ALK testing, as she had no history of smoking.
Keywords: Anaplastic large cell lymphoma (ALCL), Anaplastic lymphoma kinase (ALK), Non-Hodgkin lymphoma.
Several novel ALK inhibitors have been developed to conquer crizotinib resistance (mostly that mediated by the gatekeeper mutation).
Insight ALK Screen is inexpensive, highly sensitive and well suited to handle larger numbers of specimens than the ALK detection methods currently available.
GenASIs further adds the ability to perform “walk away” automated genetic tissue scanning for ALK using an 81 slide continues scanning robot.
The study assessed crizotinib in 76 patients with NSCLC and ALK gene fusion.
Following completion, Artu will be consolidated into ALK's Dutch subsidiary.