angiolymphoid hyperplasia with eosinophilia

(redirected from ALHE)
Also found in: Acronyms.

an·gi·o·lym·phoid hy·per·pla·si·a with e·o·sin·o·phil·i·a

solitary or multiple small benign cutaneous erythematous nodules, occurring mainly on the head and neck in young adults, characterized by dermal proliferation of blood vessels with vacuolated histiocytoid endothelial cells and with a varied infiltrate of eosinophils, lymphocytes which may form follicles, and histiocytes.
Synonym(s): Kimura disease

angiolymphoid hyperplasia with eosinophilia

An uncommon idiopathic condition with some features of Kimura disease, which presents in adults as one or more red-blue papules, plaques, or nodules in the head and neck, less commonly in the hands, shoulders, and elsewhere. It is unknown whether it is neoplastic or reactive.
Prognosis ALHE is clinically benign but persistent and treatment is refractory.


Tetsuji, 20th century Japanese pathologist.
Kimura disease - solitary or multiple small benign cutaneous erythematous nodules. Synonym(s): angiolymphoid hyperplasia with eosinophilia
Mentioned in ?
References in periodicals archive ?
The features concurred with the clinical diagnosis of ALHE.
As already started ALHE is commonly seen in the head and neck region.
KD is thought to be an allergic response, owing to the presence of eosinophilia and elevated IgE levels, whereas ALHE is believed to be a true neoplasm of the endothelium.
Mohs micrographic surgery has been attempted in order to address ALHE through better margin control.
CONCLUSION: This case is presented to discuss therapeutic challenges faced in the management of widespread recurrent ALHE when the patient refuses to undergo invasive mode of treatment.
of ALHE show damaged and/or tortuous arteries and veins at the base of the lesion, suggesting that arteriovenous shunting may play a role in the pathogenesis.
Differential diagnoses of ALHE include granuloma faciale, persistent insect bite reaction, injection site granuloma, cutaneous lymphoma, cavernous hemangioma, pyogenic granuloma, angiomatous lymphoid hamartoma, pseudolymphoma (lymphocytic infiltrate of Jessner, lymphocytoma cutis), sarcoidosis and bacillary angiomatosis.
ALHE is believed to be neoplastic in origin and to represent a benign form of a spectrum of vascular proliferations, including epithelioid hemangioendothelioma and epithelioid angiosarcoma.