angiolymphoid hyperplasia with eosinophilia

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an·gi·o·lym·phoid hy·per·pla·si·a with e·o·sin·o·phil·i·a

solitary or multiple small benign cutaneous erythematous nodules, occurring mainly on the head and neck in young adults, characterized by dermal proliferation of blood vessels with vacuolated histiocytoid endothelial cells and with a varied infiltrate of eosinophils, lymphocytes which may form follicles, and histiocytes.
Synonym(s): Kimura disease
Farlex Partner Medical Dictionary © Farlex 2012

angiolymphoid hyperplasia with eosinophilia

An uncommon idiopathic condition with some features of Kimura disease, which presents in adults as one or more red-blue papules, plaques, or nodules in the head and neck, less commonly in the hands, shoulders, and elsewhere. It is unknown whether it is neoplastic or reactive.
Prognosis ALHE is clinically benign but persistent and treatment is refractory.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Tetsuji, 20th century Japanese pathologist.
Kimura disease - solitary or multiple small benign cutaneous erythematous nodules. Synonym(s): angiolymphoid hyperplasia with eosinophilia
Medical Eponyms © Farlex 2012
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References in periodicals archive ?
Central to the histology of ALHE is the proliferation of blood vessels of varying sizes lined by plump endothelial cells.
Conclusion: ALHE is said to be more frequent in Asians and Caucasians.
KD is thought to be an allergic response, owing to the presence of eosinophilia and elevated IgE levels, whereas ALHE is believed to be a true neoplasm of the endothelium.3
In the literature various terms have been used by different authors to describe this lesion, including angioblastic hyperplasia with eosinophilia (ALHE), nodular angioblastic lymphoid hyperplasia with eosinophilia, lymphofolliculosis, histiocytoid hemangioma pseudopyogenic granuloma, and atypical pyogenic granuloma.
DISCUSSION: Patients with ALHE typically present with an expanding nodule or group of nodules, usually in the vicinity of the ear.
Angiolymphoid hyperplasia with eosinophilia (ALHE), characterized by dermal and subcutaneous nodules in head and neck areas, is often very disfiguring.
The differential diagnosis includes angiolymphoid hyperplasia with eosinophilia (ALHE), Hodgkin lymphoma, angioimmunoblastic T-cell lymphoma, Langerhans cell histiocytosis, florid follicular hyperplasia, Castleman disease, dermatopathic lymphadenopathy, allergic granulomatosis of Churg and Strauss, drug reaction, and parasitic lymphadenitis.
This finding suggested either Kimura's disease or angiolymphoid hyperplasia with eosinophilia (ALHE).
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