ALG13

ALG13

A gene on chromosome Xq23 that encodes a subunit of a bipartite UDP-N-acetylglucosamine transferase, which heterodimerises with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase. This enzyme catalyses the second sugar addition of the conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation; with ALG14, this transferase catalyses asparagine (N)-glycosylation, an essential modification that regulates protein folding and stability.
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The top 11 genes with a high absolute value of coefficient factor, namely, 4247 (mgat2), 4248 (MGAT3), 85365 (ALG2), 1650 (DDOST), 11282 (MGAT4B), 79868 (ALG13), 57134 (MAN1C1), 8813 (DPM1), 4122 (MAN2A2), 146664 (MGAT5B), and 29929 (ALG6), are selected to represent the genes for this canonical variable (Figure 4(b), Table 1).
Gene mutation is considered to be responsible for agnogenic EOEEs.[9] With the extensive application of next-generation sequencing (NGS) and whole exome sequencing, EOEE-related gene panels make for early and efficient diagnosis of EOEE patients and also help detecting more EOEE susceptibility genes.[10] STXBP1, ARX, SLC25A22, and KCNQ2 are some of the susceptibility genes for OS, while CDKL5, ALG13, and SCN1A are considered to be responsible for WS.