ALG12

ALG12

A gene on chromosome 11q14.1 that encodes a member of the glycosyltransferase 22 family which catalyses the addition of the 8th mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)), which is required for protein glycosylation.
 
Molecular pathology
ALG12 is mutated in congenital disorder of glycosylation type Ig (CDGIg).
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References in periodicals archive ?
PIG-B, PIG-Z, and two [alpha]-mannosyltransferases, ALG9 and ALG12, in the N-glycosylation pathway form a protein family, supporting the idea that PIG-B is GPI-mannosyltransferase III.
This intermediate is then flipped from the cytosol to the rER lumen, where synthesis proceeds by GTs Alg3, Alg9, Alg12, Alg6, Alg8, and Alg10 that use the dolichol-linked sugars Dol-PP-Glc and Dol-PP-Man as donors to synthesize the glycan precursor Dol-PP-GlcN[Ac.sub.2] [Man.sub.9] [Glc.sub.3].
ALG12 mannosyltransferase defect in congenital disorder of glycosylation type 1g.