ALG11

ALG11

A gene on chromosome 13q14.2 that encodes GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, an enzyme localised to the cytosolic side of the endoplasmic reticulum that catalyses the transfer of the 4th and 5th mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol, resulting in the production of Man5GlcNAc2-PP-dolichol.

Molecular pathology
ALG11 is mutated in congenital disorder of glycosylation type Ip (CDGIp).
References in periodicals archive ?
GTF2F2, general transcription factor IIF polypeptide 2; SPERT, spermatid associated; HTR2A, 5-hydroxytryptamine receptor 2A; WDFY2, WD repeat and FYVE domain containing 2; ALG11, asparagine-linked glycosylation 11; CKAP2, cytoskeleton associated protein 2; GTF2F2, general transcription factor IIF polypeptide 2; KCTD4, potassium channel tetramerization domain containing 4.
albicans orthologue GTs Alg7, Alg13/14, Alg1, Alg2, and Alg11, using the nucleotide sugars UDPGlcNAc and GDP-Man as donor substrates to synthesize the Dol-PP-GlcN[Ac.sub.2][Man.sub.5] intermediate.
Orden Denominacion Direccion 1 2 A7 Santa Tecla NE-NNE 2 2 A8 Ponferrada E-O 3 3 L8 Constancia NO-N-S 4 3 L16 Muros e Noia NE-NO-E-O 5 4 ALG1 Laxe NO-N-S 6 4 ALG2 Betanzos NO-SE 7 4 ALG3 Ares E-O-NO-SE 8 4 ALG4 Barqueiro NNE-NE 9 4 ALG5 Ribadeo NE 10 4 ALG6 E de Villalba NNE-N-S 11 4 ALG7 Belesar NE-N-S 12 4 ALG8 O de Lalin NO-N-S 13 4 ALG9 Aurosa NE 14 4 ALG10 Viana do Bollo N-S-NE 15 4 ALG11 Xinzo de Limia NE 16 4 ALG12 Bande NO 17 4 ALG13 A Fonsagrada NE Alin.