ALG10

ALG10

A gene on chromosome 12p11.1 that encodes an enzyme that catalyses the transfer of the terminal (third) glucose residue from dolichyl phosphate glucose (Dol-P-Glc) to the lipid-linked oligosaccharide (Glc2Man9GlcNAc(2)-PP-Dol) precursor for N-linked glycosylation.
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This intermediate is then flipped from the cytosol to the rER lumen, where synthesis proceeds by GTs Alg3, Alg9, Alg12, Alg6, Alg8, and Alg10 that use the dolichol-linked sugars Dol-PP-Glc and Dol-PP-Man as donors to synthesize the glycan precursor Dol-PP-GlcN[Ac.sub.2] [Man.sub.9] [Glc.sub.3].