ALDH6A1

ALDH6A1

A gene on chromosome 14q24.3 that encodes a mitochondrial methylmalonate semialdehyde dehydrogenase, an aldehyde dehydrogenase, which is involved in valine and pyrimidine catabolism. It causes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA.
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References in periodicals archive ?
In a recent study, several genes involved in BCAA catabolism were downregulated in muscle from insulin-resistant subjects [26]; the highest correlation was seen with MUT and ALDH6A1, both involved in valine catabolism downstream of 3-HIB.
Higher Concentrations of BCAAs and 3-HIB Are Associated with Insulin Resistance in the Transition from Gestational Diabetes to Type 2 Diabetes
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