ALDH1A3

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ALDH1A3

A gene on chromosome 15q26.3 that encodes an aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation, either in a free or cellular retinol-binding protein form.
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These genes encoded proteins primarily involved in integrin signalling pathways (ACTA2, PIK3C2G, COL4A6, CAV1, LAMA1, FN1, and ITGA8), regulation of hormone levels (NR5A1, TIPARP, ACE, CRYM, CGA, ALDH1A1, TBX3, POMC, GHRH, and ALDH6), camera-type eye development (TGFBR2, BMP4, FABP7, STRA6, SIX6, and WNT6), blood vessel development (Figure S1, goo.gl/tC9GTZ), and regulation of cellular response to growth factor stimulus (see Figure 2).
In 3-week-old cockerels, three genes (LECT2, CGA, and ALDH6) showed over tenfold higher expression than that in 6-week-old birds.
Nevertheless, this intensive growth rate was reflected in the hypothalamic activity, because numerous genes associated with hormone status regulation were overexpressed (CGA, ALDH1A1, TBX3, IGF2, POMC, GHRH, and ALDH6).
Retinol and alcohol dehydrogenases convert the sequestered retinol to retinal, which is then converted to RA by retinal dehydrogenases such as ALDH6 (Rexer et al.
The predominant linkage to RAR is through upregulation of ALDH6 and CFP1A 1, which synthesize RA.
The network depicted in Figure 2 was developed to test the hypothesis of a linkage between dioxin-responsive genes CYP1A1 and ALDH6, and the RAR-signaling gene RARB.
Similarly, 54% found the linkage between ALDH6 and RARB to be significant.