ALDH2


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ALDH2

A gene on chromosome 12q24.2, which encodes a protein belonging to the aldehyde dehydrogenase (ALDH) family of proteins, and is the second enzyme of the major oxidative pathway of alcohol metabolism. The two major liver isoforms of ALDH, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities. Most Caucasians have both; 50% of Asians have only the cytosolic isozym, making them more susceptible to acute alcohol intoxication.
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(2014) ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: A meta-analysis.
Coronary artery spasm--Clinical features, pathogenesis and treatment--
People who drink alcohol regularly and have the ALDH2 alleles, are 50 times more likely to develop esophageal cancer than those with the alleles who are non-drinkers.
Risk of esophageal cancer high in Taiwan due to 'Asian Flush'
Osier et al., "Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population," Human Genetics, vol.
Building Up a Robust Risk Mathematical Platform to Predict Colorectal Cancer
Meanwhile, we detected an enhanced mitochondrial ALDH2 activity (Figure 5(d)) and a significant reduction in 4-HNE accumulation (Figure 5(e)) in reperfusion-injured myocardium of WT mice, but not in that of PKC[epsilon]-DN mice.
Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury
Zhou, "Mir-28 promotes cardiac ischemia by targeting mitochondrial aldehyde dehydrogenase 2 (aldh2) in mus musculus cardiac myocytes," European Review for Medical and Pharmacological Sciences, vol.
MicroRNA as a Therapeutic Target in Cardiac Remodeling
Aldehyde dehydrogenase 2 (ALDH2) is a homotetramer enzyme located in the mitochondrial matrix.
Association between Carotid Intima-media Thickness and Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism in Chinese Han with Essential Hypertension
The variation in alcohol elimination and the oxidation of acetaldehyde, genetically determined alcohol dehydrogenase 1-3 (before named ADH1A, ADH1B and ADH1C) and aldehyde dehydrogenase (ALDH2) plays a major role in the pathogenesis of the clinical syndrome.
Characterization of polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 and relationship to the alcoholism in a Colombian population/Caracterizacion de polimorfismos de los genes ADH2, ADH3, ALDH2 y CYP2E1 y su relacion con el alcoholismo en una poblacion colombiana
En dependencia de alcohol, los GWAS han confirmado la implicacion ya conocida de ALDH2 o la familia de ADH y han identificado unos pocos genes adicionales, como PECR o NKAIN1-SERINC2 (Frank et al., 2012; Treutlein et al., 2009; Zuo et al., 2013).
Un abordaje genomico del alcoholismo
In Asians, the ALDH2*2 allele, which encodes for an inactive ALDH2 form, appears to protect against alcoholism [14,15].
Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis
Tanto los genes que codifican la ADH2 y la ADH3, ubicados en el cromosoma 4, como el gen ALDH2 localizado en el cromosoma 12, presentan polimorfismos con trascendencia funcional.
Interaction between Rs671 Polymorphism of the ALDH2 Gene and Alcohol Consumption in Chilean Individuals/ Analisis de la Interaccion entre el Polimorfismo Rs671 del Gen ALDH2 y Consumo de Alcohol en Individuos Chilenos
Residing on Chromosome 12 at chromosomal nucleotide position 111803962, this occurs within the gene for aldehyde dehydrogenase 2 (ALDH2).
Personalized medicine, pharmacogenomics, and companion diagnostics: current and future applications of molecular diagnostics will influence these emerging fields

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