ALDH2


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ALDH2

A gene on chromosome 12q24.2, which encodes a protein belonging to the aldehyde dehydrogenase (ALDH) family of proteins, and is the second enzyme of the major oxidative pathway of alcohol metabolism. The two major liver isoforms of ALDH, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities. Most Caucasians have both; 50% of Asians have only the cytosolic isozym, making them more susceptible to acute alcohol intoxication.
References in periodicals archive ?
(2014) ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: A meta-analysis.
People who drink alcohol regularly and have the ALDH2 alleles, are 50 times more likely to develop esophageal cancer than those with the alleles who are non-drinkers.
Osier et al., "Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population," Human Genetics, vol.
Meanwhile, we detected an enhanced mitochondrial ALDH2 activity (Figure 5(d)) and a significant reduction in 4-HNE accumulation (Figure 5(e)) in reperfusion-injured myocardium of WT mice, but not in that of PKC[epsilon]-DN mice.
Zhou, "Mir-28 promotes cardiac ischemia by targeting mitochondrial aldehyde dehydrogenase 2 (aldh2) in mus musculus cardiac myocytes," European Review for Medical and Pharmacological Sciences, vol.
The variation in alcohol elimination and the oxidation of acetaldehyde, genetically determined alcohol dehydrogenase 1-3 (before named ADH1A, ADH1B and ADH1C) and aldehyde dehydrogenase (ALDH2) plays a major role in the pathogenesis of the clinical syndrome.
En dependencia de alcohol, los GWAS han confirmado la implicacion ya conocida de ALDH2 o la familia de ADH y han identificado unos pocos genes adicionales, como PECR o NKAIN1-SERINC2 (Frank et al., 2012; Treutlein et al., 2009; Zuo et al., 2013).
In Asians, the ALDH2*2 allele, which encodes for an inactive ALDH2 form, appears to protect against alcoholism [14,15].
Tanto los genes que codifican la ADH2 y la ADH3, ubicados en el cromosoma 4, como el gen ALDH2 localizado en el cromosoma 12, presentan polimorfismos con trascendencia funcional.
Residing on Chromosome 12 at chromosomal nucleotide position 111803962, this occurs within the gene for aldehyde dehydrogenase 2 (ALDH2).
Durante los estudios de genes candidatos se han identificado los dos genes verificados de la adiccion que codifican las enzimas del metabolismo del alcohol: el alcohol deshidrogenasa ADH, gen ADH1B y el aldehido deshidrogenasa ALDH, gen ALDH2 (Befort 2001).