ALDH1B1

ALDH1B1

A gene on chromosome 9p11.1 that encodes an aldehyde dehydrogenase that plays a key role in detoxifying aldehydes generated by alcohol metabolism.
References in periodicals archive ?
The ALDH1A1 enzyme is found in the cytosol, whereas both ALDH1B1 and ALDH2 are produced in the nucleus but have leader sequences that direct them to cell components called mitochondria, where they exert their functions in the mitochondrial interior (i.
It is likely that the ALDH1A1 and ALDH1B1 enzymes significantly contribute to acetaldehyde metabolism only in situations where ALDH2 is inactivated, either pharmacologically or because of the presence of the ALDH2*2 allele.
The team studied colon cancers from 40 patients and found a form of this enzyme known as ALDH1B1 present in every colon cancer cell in 39 out of the 40 cases.
It appears that ALDH1B1 aids the development or growth of these cancer cells because it would not be present in every cell at such high levels if it were simply a byproduct of the cancer.
Vasiliou's team studied colon cancers from 40 patients and found a form of this enzyme known as ALDH1B1 present in every colon cancer cell in 39 out of the 40 cases.