ALDH1A3

ALDH1A3

A gene on chromosome 15q26.3 that encodes an aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation, either in a free or cellular retinol-binding protein form.
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The candidate genes have the highest of genetic variance of 5 adjacent SNPs for each trait were aldehyde dehydrogenase 1 family member A3 (ALDH1A3) gene located on SSC1 for PWL (4.27%); leucine rich repeat kinase 1 (LRRK1) gene located on SSC1 for BAL (4.86%) and W2CL (3.66%); retrotransposon Gag like 4 (RTL4) located on SSCX for LSY (1.64%) and PWSY (1.86%).
The ALDH1A3 and LRRK1 were found on every trait in Large White pigs, which located on SSC1.
Meanwhile, five genes were identified to be candidate genes in Large White, which associated with all of six reproduction traits included ALDH1A3 and LRRK1 and five traits except W2CL were RTL4, TRPC5, and LHFPL1.
ALDH1A3, a metabolic target for cancer diagnosis and therapy.
Alterations in dosage-sensitive transcription factor genes (such as SOX2 (OMIM 184429), OTX2 (OMIM 600037), and PAX6 (OMIM 607181)) and retinoic acid metabolism genes (such as STRA6 (OMIM 610745), ALDH1A3 (OMIM 600463), and RARB (OMIM 180220)) [13].
For example, increased abundance of Aldh1a3 and reduced nuclear presence of the transcription factor Nkx6.1 were observed in pancreatic islets from T2D, but not in healthy controls [14].
(4) While both WD-fed C57BL/6J mice and db/db mice exhibit adaptive increases in islet size, the db/db mice also display increased islet expression of the dedifferentiation marker Aldh1a3. (5) There is reduced nuclear presence of the transcription factor Nkx6.1 in db/db mice when compared with mice fed the WD.
Briefly, the antibodies used were as follows: insulin (Invitrogen; 18-0067; used at 1: 800), glucagon (Cell Signaling Technologies; 8233; used at 1: 400), Aldh1a3 (Novus Biologicals; NBP2-15339; used at 1:100), and Nkx6.1 (F55A12; 1:200; [21]).
Supporting this hypothesis, tumor samples excised from the treated animals exhibited higher expression of DDIT3 and lower levels of ALDH1A3, an isoform of aldehyde dehydrogenase found to be over expressed in pemetrexed + cisplatin resistant MPM cells, which augments the chemosensitizing effect of butein (Canino et al.
A STAT3-NFkB/DDIT3/CEBP[beta] axis modulates ALDH1A3 expression in chemoresistant cell subpopulations.
HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: array-based DNA methylation and expression profiling.
Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation.