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In order to provide further information of GA on the sternness of DPCs, the expression levels of stem cell markers including CD133, integrin [beta]1 and ALDH1A1 in response to GA treatment in time- and concentration-dependent manners were determined by western blot analysis.
However, researchers have found that another polymorphism, called ALDH1A1*2 in the ALDH1A1 gene, is associated with greater risk for alcoholism in African populations (Moore et al.
An interesting observation was noted for sample CTC003, in which CTC status was defined as negative by AdnaGen assay on the basis of the low expression of 7 selected genes [EPCAM (epithelial cell adhesion molecule), MUC1 (mucin 1, cell surface associated), ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, [HER2]), AKT2 (v-akt murine thymoma viral oncogene homolog 2), PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), TWIST1 (twist family bHLH transcription factor 1), and ALDH1A1 (aldehyde dehydrogenase 1 family, member A1)], but still showed an expression for PAM50 panel genes not dissimilar from that of true CTC-positive samples.
Our image analysis along with in-depth spot analysis (lower panel of Figure 4A, B and C) revealed omental depot with higher expressions of ANXA 6, HSPB1, TAGLN, ALDH1A1 and CALD 1, whereas in the subcutaneous depot, expressions of PRDX 6 and GSN were found to be high.
The PB1 crystallin was found higher expression in CCA patients and in ALDH1A1 no significant differences was noticed.
ALDH1A1 Miembro A1 de la familia 1 de aldehido deshidrogenasa.
the cytosol) and is encoded by the ALDH1A1 gene, and ALDH2, which is found in the mitochondria and is encoded by the ALDH2 gene.
The ALDH1A1 enzyme is found in the cytosol, whereas both ALDH1B1 and ALDH2 are produced in the nucleus but have leader sequences that direct them to cell components called mitochondria, where they exert their functions in the mitochondrial interior (i.
1) Spence and colleagues (2003), who studied people with a variety of ethnic backgrounds, recently identified polymorphisms of the ALDH1A1 gene resulting in three gene variants (i.
The Km values (3) of the ALDH1A1 and ALDH1B1 enzymes exceed those of the ALDH2 enzyme by at least 100-fold, and, thus, are not likely to be operating at full capacity when acetaldehyde levels are kept at the usual physiological state (i.
ALDH1, which is encoded by the ALDH1A1 gene, has been associated with alcoholism, alcohol-induced flushing, and alcohol sensitivity (Chan 1986; Yoshida 1992).
Among Afro-Trinidadians, however, the small number of subjects with atypical ALDH1A1 polymorphisms limited any conclusions on the possible impact on alcoholism in that population (Moore et al.
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- aldehyde dehydrogenase (acylating)
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