ALDH1A1

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ALDH1A1

A gene on chromosome 9q21.13 that encodes a cytosolic aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation. The ALDH1A1 gene may be involved in regulating the metabolic responses to a high-fat diet.
References in periodicals archive ?
Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal like breast cancers.
They then isolated ALDH1 positive cells, sequenced their genetic profiles and found many markers previously reported for stem cells in other organs.
Bmi-1 regulates snail expression and promotes metastasis ability in head and neck squamous cancer-derived ALDH1 positive cells.
Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago.
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
The addition of magnesium ions to these ALDH systems modulates activity, in some cases increasing activity (ALDH2) and in others, like ALDH1, decreasing activity.
For acetaldehyde metabolism, ALDH1 (cytosolic) and ALDH2 (mitochondrial) appear to be the most important, with the mitochondrial form contributing most of the clearance.
In our studies, the expression of ALDH1 in tumor cells was not associated with response or resistance to therapy; intriguingly, stromal expression was found to be prognostic in triple-negative tumors.
Boman adds that his team decided to focus on ALDH1 because it had previously been identified as a marker for leukemias, brain cancers, and breast cancer.
A variant of the ALDH1 enzyme that is encoded by the ALDH1A1*2 allele, however, was found in a small proportion of a group of Southwest California Indians and had a protective effect against alcoholism in that population.
The expression of CSC markers such as CD44, CD24, and ALDH1 has also been shown in CTCs by both molecular assays (42) and imaging (73).