ALDH1A1

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ALDH1A1

A gene on chromosome 9q21.13 that encodes a cytosolic aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation. The ALDH1A1 gene may be involved in regulating the metabolic responses to a high-fat diet.
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cells) still retain their pluripotency and tumorigenicity under this culture condition, as indicated by higher Oct-4 and ALDH1 mRNA expression, as well as higher mammosphere forming unit compared to their counterpart [CD24.
Para el analisis de los casos, se agruparon los 22 marcadores utilizados en cuatro grupos: a) marcadores de la clasificacion molecular (ER, PR y HER2), b) marcadores de proliferacion celular y otros (EGFR, C-Kit, p63, survivina, ALDH1, CD10 y Ki-67), c) marcadores de filamentos intermedios (Ck5/6, CK8/18, CK14, CK17, CK APM y vimentina), d) marcadores de adhesion celular y citoesqueleto (cadherina E, cadherina P, p120, actina de musculo liso, alfa actina y calponina).
Together with other stem cell markers, GA was shown to induce the loss of stem cell features in DPCs as indicated by the significant decrease of CD133, ALDH1 Al, and integrin [beta]1 (Fig.
Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago.
The analysis of tumor samples from patients who had undergone first-line chemotherapy showed an enrichment of stem cell markers, such as CD133, CD44, and ALDH1, compared with samples obtained during surgical cytoreduction.
Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal like breast cancers.
They then isolated ALDH1 positive cells, sequenced their genetic profiles and found many markers previously reported for stem cells in other organs.
Bmi-1 regulates snail expression and promotes metastasis ability in head and neck squamous cancer-derived ALDH1 positive cells.
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
The addition of magnesium ions to these ALDH systems modulates activity, in some cases increasing activity (ALDH2) and in others, like ALDH1, decreasing activity.
For acetaldehyde metabolism, ALDH1 (cytosolic) and ALDH2 (mitochondrial) appear to be the most important, with the mitochondrial form contributing most of the clearance.