ALDH1A1

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ALDH1A1

A gene on chromosome 9q21.13 that encodes a cytosolic aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation. The ALDH1A1 gene may be involved in regulating the metabolic responses to a high-fat diet.
References in periodicals archive ?
Cancer stem cell (CSC) is centered in the Cancer stem cell model of carcinogenesis and this idea is enriched by increased expression of the pluripotent stem cell markers like OCT4, SOX2, NANOG in HNSCC cell lines and other CSC markers like ABCG2, CD44, and ALDH1 that are proverbial to have tumour-inducing potential.
Tenders are invited for Equipment for prognostic significance of aldh1, bmi1 & oct4 in oral epithelial dysplasia and oral squamous cell carcinoma at fds, ramaiah university of applied sciences, gnanagangothri campus, bengaluru-sponsored by vgst
The utility of STAT6 and ALDH1 expression in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms.
A novel multiplex RT-qPCR assay was developed for PSCA, ALDH1, PROM1, and HPRT1 gene transcripts.
Zavras, "Alcohol intake and folate antagonism via CYP2E1 and ALDH1: Effects on oral carcinogenesis," Medical Hypotheses, vol.
[11] in which it was reported that "HMGA2 increased the expression of the stem cell markers CD44, ALDH1, Sox2, and Oct4 and the EMT-related factors Snail and [beta]-catenin" in gastric cancer cells.
Moreover, ALDH1, the dominant form in the family of ALDH involved in the conversion of retinaldehyde to retinoic acid, is a recognized marker [117].
We previously showed that normal colonic SCs are found at the base of the normal human colon crypt and can be isolated using SC markers such as aldehyde dehydrogenase (ALDH1), ALCAM (CD166), and LGR5 [46-48].
ATX-LPA axis has been shown to induce chemoresistance by upregulating antioxidant genes, multidrug-resistant transporters (ABCC1, ABCG2, ABCC2, and ABCC3), aldehyde dehydrogenase 1 (ALDH1), and stem cell maintenance [99, 136].
Although there are no specific growth factors for stem cells, the human BCSCs ([CD24.sup.-]/[CD44.sup.+] cells) still retain their pluripotency and tumorigenicity under this culture condition, as indicated by higher Oct-4 and ALDH1 mRNA expression, as well as higher mammosphere forming unit compared to their counterpart [CD24.sup.-]/[CD44.sup.-] cells and the unsorted primary breast cancer cells (Patent registration from the General Directorate of Intellectual Property Right, Ministry of Law and Human Right, Republic of Indonesia; No.
Based on the early research finding that retinol was oxidized to retinaldehyde by the enzyme similar to ADH1 [6], retinaldehyde was oxidized to retinoic acid by aldehyde dehydrogenase 1 (ALDH1) [13].
Orouji et al., "Differential diagnosis of solitary fibrous tumors: a study of 454 soft tissue tumors indicating the diagnostic value of nuclear STAT 6 relocation and ALDH1 expression combined with in situ proximity ligation assay," International Journal of Oncology, vol.