anaplastic large cell lymphoma

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Related to ALCL: ACL

an·a·plas·tic large cell lym·pho·ma

a form of lymphoma characterized by anaplasia of cells, sinusoidal growth, and immunoreactivity with CD30 (Ki-1 or Ber-H2).
Synonym(s): Ki-1+ lymphoma

anaplastic large cell lymphoma

A primary non-B cell non-Hodgkin lymphoma, usually of T cell lineage, which is immunoreactive for CD30 and often ALK (anaplastic lymphoma kinase) and characterised by scattered to abundant “hallmark cells”—medium-sized cells with abundant cytoplasm and kidney-shaped nucleus, which tend to aggregate around blood vessels. ALCLs arise either as a primary neoplasm in a node or lymphoid tissue, soft tissue, lung, or skin, or secondary to the transformation of a lymphoproliferative disorder (e.g., mycosis fungoides), T-cell lymphoma, lymphomatoid papulosis or Hodgkin lymphoma.
DiffDx Classical Hodgkin lymphoma.
Clinical findings Often a late-presenting lymphoma with “B symptoms” including night sweating and weight loss.
Molecular >90% have rearrangement of T cell receptor, chromosomal translocation involving the nucleophosmin gene on chromosome 5.
Management CHOP, radiation for bulky disease.

anaplastic large cell lymphoma

Abbreviation: ALCL
A rare form of non-Hodgkin, T-cell lymphoma that may behave indolently when limited to the skin or may be more aggressive and spread to lymph nodes throughout the body.
See also: lymphoma
References in periodicals archive ?
As a leading pharmaceutical company in the oncology field in Japan, Chugai will work to provide Alecensa as a new treatment option for ALK-positive ALCL as soon as possible.
But though this may only be the first case, the authors of the study insisted that medical professionals should "recognize that patients with textured silicone implants other than breast implants may also be at risk of ALCL." People who are considering getting butt implants, particularly the textured kind, need to be informed of the possible risks and complications, the researchers said.
The ALCL group spent the least amount of time in the target quadrant (4.5 [+ or -] 1.2 s), while the highest was seen with the DONZ 3 mg/kg group (28.83 [+ or -] 2.13 s).
Vose et al., "ALK--anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK + ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project," Blood, vol.
(reporting odds ratio estimate of 18.2 for ALCL in women with breast implants); Patients Considering Breast Implants Need Information on Risk of Very Rare Cancer, AM.
There are two known subtypes of ALCL of the breast: (a) in situ, in which disease proliferation is confined to the capsule and is often associated with seroma as in our patient, and (b) infiltrative, mostly associated with tumor mass with cells infiltrating the capsule and adjacent tissues [2].
ALCL is a rare type of blood cancer more common in young people, mostly boys.
Purpose: Therefore, we analysed whether the active principles that were recently isolated and found to inhibit inflammatory responses specifically inhibit growth of NPM/ALK+ ALCL, leukaemia and breast cancer cells, but not of normal cells, and the intravasation through the lymphendothelial barrier.
Material and Methods: A total of twenty five consecutive biopsy proven cases of anaplastic large cell lymphoma (ALCL) were selected through non probability, consecutive sampling.
- Anaplastic Large Cell Lymphoma (ALCL) - Pipeline Review, H1 2015
Persistent expression of SOCS1 and/or SOCS3 is observed in several haematological malignancies such as cutaneous T cell lymphoma (CTCL), chronic myeloid leukemia (CML), ALK+ anaplastic large cell lymphoma (ALCL), and some acute leukemia.