anaplastic large cell lymphoma

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Related to ALCL: ACL

an·a·plas·tic large cell lym·pho·ma

a form of lymphoma characterized by anaplasia of cells, sinusoidal growth, and immunoreactivity with CD30 (Ki-1 or Ber-H2).
Synonym(s): Ki-1+ lymphoma

anaplastic large cell lymphoma

A primary non-B cell non-Hodgkin lymphoma, usually of T cell lineage, which is immunoreactive for CD30 and often ALK (anaplastic lymphoma kinase) and characterised by scattered to abundant “hallmark cells”—medium-sized cells with abundant cytoplasm and kidney-shaped nucleus, which tend to aggregate around blood vessels. ALCLs arise either as a primary neoplasm in a node or lymphoid tissue, soft tissue, lung, or skin, or secondary to the transformation of a lymphoproliferative disorder (e.g., mycosis fungoides), T-cell lymphoma, lymphomatoid papulosis or Hodgkin lymphoma.
DiffDx Classical Hodgkin lymphoma.
Clinical findings Often a late-presenting lymphoma with “B symptoms” including night sweating and weight loss.
Molecular >90% have rearrangement of T cell receptor, chromosomal translocation involving the nucleophosmin gene on chromosome 5.
Management CHOP, radiation for bulky disease.

anaplastic large cell lymphoma

Abbreviation: ALCL
A rare form of non-Hodgkin, T-cell lymphoma that may behave indolently when limited to the skin or may be more aggressive and spread to lymph nodes throughout the body.
See also: lymphoma
References in periodicals archive ?
Peripheral blood involvement is rare and is most often seen in pediatric small cell variant ALK+ ALCL but has been reported in adults and ALK- tumors.
The small cell variant of ALCL has been reported in association with the common variant, the lymphohistiocytic variant, as well as in association with the dual occurrence of the common and lymphohistiocytic variants.
Anderson Cancer Center (Houston) were searched for cases of ALCL in which a specimen was submitted for flow cytometry.
As a positive control, we used an ALK-positive ALCL case generously provided by John K.
Systemic ALCL which can affect all organs in the body is aggressive; and primary cutaneous ALCL which is confined to the skin is slow-growing.
Results: In vitro treatment of ALCL by neurolenin B suppressed NPM/ALK, JunB and PDGF-R[beta] expression, inhibited the growth of ALCL cells late in M phase, and induced apoptosis via caspase 3 without compromising mitochondrial activity (as a measure of general exogenic toxicity).
Therefore, ALCL was defined as a disease with a T cell or null-cell phenotype in the revised European- American lymphoma classification scheme3.
The marked cellular pleomorphism and variation of ALCL raises a broad differential diagnosis including hematopoietic and nonhematopoietic neoplasms.
Here, we present an extremely rare case of ALCL in a woman who had breast implants for more than a decade.
Initially reports also linked the implants to a rare form of cancer known as ALCL, but that has been now been discounted by medical experts in the UK and Europe.
It said it had received no reports of ALCL linked with breast implants in the UK, adding: "Discussions with the relevant UK professional bodies have not identified any cases.