AKT3

AKT3

A gene on chromosome 1q44 that encodes protein kinase B (PKB), a member of the serine-threonine protein kinase family, which regulate cell signalling in response to insulin and growth factors and are involved in an array of biological processes including cell proliferation, differentiation, apoptosis and tumourigenesis, as well as glycogen synthesis and glucose uptake. PKB is stimulated by platelet-derived growth factor (PDGF), insulin and insulin-like growth factor 1.
References in periodicals archive ?
AKT3 appears to play a key role in brain growth, with mice whose AKT3 gene is silenced showing smaller brain size.
Nevertheless, different studies have shown association between iHME and mutations in AKT3, PIK3CA and MTOR genes.
A total of 16 of 17 changes were concordant in OncoPanel, with the exception of an AKT3 high-copy gain in 1 glioblastoma.
Its brands include AKT 2, AKT3, AKURIT3, BUDAMATE 100 TRANSCAPS, BUDAMATE 100 HFA TRANSHALER, BUDATE 100 HFA TRANSHALER (MDI), and BUDATE 200 HFA TRANSHALER (MDI).
Mutations in three genes, AKT3, PIK3R2 and PIK3CA, were also found to be associated with a constellation of disorders including cancer, hydrocephalus, epilepsy, autism, vascular anomalies and skin growth disorders.
Mapping of AKT3, encoding a member of the Akt/protein kinase B family, to human and rodent chromosomes by fluorescence in situ hybridization.
ATPP2Ca negatively regulates ABA responses during cold acclimation and interacts with the potassium channel AKT3.
In TNBC, Akt3-MAGI3 fusions have been reported to upregulate the expression of AKT3, while removing the PDZ [PSD95 (postsynaptic density protein), Dlg1 (Drosophila disc large tumor suppressor), and zo-1 (zonula occludens-1 protein)] domain of MAGI3, required for PTEN binding.