AKT3

AKT3

A gene on chromosome 1q44 that encodes protein kinase B (PKB), a member of the serine-threonine protein kinase family, which regulate cell signalling in response to insulin and growth factors and are involved in an array of biological processes including cell proliferation, differentiation, apoptosis and tumourigenesis, as well as glycogen synthesis and glucose uptake. PKB is stimulated by platelet-derived growth factor (PDGF), insulin and insulin-like growth factor 1.
References in periodicals archive ?
Akt is Ser/Thr kinase which is also referred to as protein kinase B (PKB) in mammalian genomes have three Akt genes namely: Akt1 (Protein kinaseB [alpha]), Akt2 (Protein kinaseB [beta]) and Akt3 (Protein kinaseB [gamma]) and they are extensively expressed in various tissues.
Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.
Akt3 (expressing circRNA53) affects the insulin-like growth factor-I-mediated signaling and survival in myoblasts [33,34].
AKT1 or of cellular growth and proliferation, such as AKT3 and PIK3CA, transcriptional regulators, such as STAT3, POLR2A, and GL1, cellular apoptosis coordinators, including arachnoid location, such as TRAF7, c-fos, or bcl-2, Hedgehog pathway regulating adult stem cells, involved in maintenance and regeneration of adult tissues, such as SMO and SUFU, cellular motility coordinators, i.e.
AKT3 appears to play a key role in brain growth, with mice whose AKT3 gene is silenced showing smaller brain size.
Endochondral Actin Focal ossification cytoskeleton adhesion VEGFA FGF2 COL11A1 ADAMTS4 FGFR1 COL3A1 PLAT4 TMSB4X COL4A1 COL10A1 GNA13 COL4A2 TGFB2 PDGFA COL4A4 PTHrP FGF1 COL5A1 FGF2 ENAH COL5A2 C4ST1 MSN COL1A1 FGFR1 GSN LAMC2 PDGFRB PDGFRB THBS2 COL1 KRAS CAV2 MRAS ARHGAP5 SOS2 PTEN AKT3 PDGFA PDGFC PGF ITGA2 PDGFRB RAP1B MAPK8 TGF[beta] MAPK signaling signaling Adipogenesis SMURF1 MAPK8 FOXO1A MAPK8 NGFB TRIB3 SKP1 PDGFRB PCK2 NEDD9 RASA2 EGR2 ETS1 SOS2 DDIT3 KLF11 KRAS GADD45A ATF3 MRAS GADD45B FOSB NF1 HIF1A SKIL RAP1B IRS1 SMURF1 DUSP1 MEF2D ZFYVE16 DDIT3 FAS HSPB1 SPOCK IL1A FAS TGFB2 MAP313 ZAK AKT3 MAP3K8 GADD45A Table 2: Genes involved in osteogenesis-related pathways that are downregulated in CYD-treated hMSCs.
Nevertheless, different studies have shown association between iHME and mutations in AKT3, PIK3CA and MTOR genes.
Also termed RAC-PK ("related to the A and C kinases"), the Akt isoforms comprise a family of three members -Akt1 (PKB-[alpha]), Akt2 (PKB-[beta]), and Akt3 (PKB[gamma])--and their activities are very susceptible to metabolic alterations such as obesity, insulin resistance, and type 2 diabetes (18).
A total of 16 of 17 changes were concordant in OncoPanel, with the exception of an AKT3 high-copy gain in 1 glioblastoma.
Mutations of the RAS pathway included those encoded by the ERBB2, KRAS, BRAF, and EGFR genes, while in the PI3K pathway, PIK3CA, PTEN, AKT1, and AKT3 were found to be mutated.
Zhu et al., "Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease," Oncotarget, vol.