AKT1


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Related to AKT1: Proteus syndrome, AKT3

AKT1

A gene on chromosome 14q32.32|14q32.32 that encodes protein kinase B (PKB), a serine-threonine protein kinase that is rapidly and specifically activated by platelet-derived growth factor through phosphatidylinositol 3-kinase. PKB plays a key role in regulating cell survival, insulin signalling, angiogenesis, tumour formation and growth factor-induced neuronal survival. Activated AKT1 phosphorylates and inactivates components of the apoptotic machinery.
References in periodicals archive ?
Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.
A potassium channel, OsAKT1, homologous to the Arabidopsis root inward rectifier AKT1 was isolated.
Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.
In EAT, there were increases in the insulin receptor ( IR) and IR substrate 2 ( IRS2) mRNA, but CE-induced increases in mRNA expression of IRS1, phosphoinositide-3-kinase, AKT1, glucose transporters 1 and 4, and glycogen synthase 1 expression and decreased trends in mRNA expression of glycogen synthase kinase 3beta were not statistically significant.
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
A eles, podem-se acrescentar os resultados de um prestigioso estudo multicentrico europeu de 2008, que testou a relacao entre esquizofrenia e catorze dos principais nucleotideos unicos associados pela literatura (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT e ARVCF), nao encontrando relacao significativa para nenhum deles, o que per se relativiza a atratividade de Hipoteses Etiologicas Unificadas em geral (Sanders, et al.
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2:amplification of AKT1 in a primary human gastric adenocarcinoma.
Within the AKT cascade, the response variable consisted of eight correlated gene expression values for each placenta--that is, two biopsies per placenta and four target genes (BDNF, AKT1, AKT2, and AKT3) measured in each biopsy.
Combined effects of genetic variants of the PTEN, AKT1, MDM2 and p53 genes on the risk of nasopharyngeal carcinoma.
6] Human genes: EGFR, epidermal growth factor receptor; KRAS, Kirsten rat sarcoma viral oncogene homolog; TP53, tumor protein p53; NF2, neurofibromin 2 (merlin); AKT1, v-akt murine thymoma viral oncogene homolog 1; BRAF, B-Raf proto-oncogene, serine/ threonine kinase; NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; KMT2D, lysine (K)-specific methyltransferase 2D; NSD1, nuclear receptor binding SET domain protein 1; CREB3L1, cAMP responsive element binding protein 3-like 1; TPR, translocated promoter region, nuclear basket protein; TSC2, tuberous sclerosis 2.