Teer et al., "A mosaic activating mutation in AKT1
associated with the proteus syndrome," New England Journal of Medicine, vol.
Yu et al., "Loss of Akt1
leads to severe atherosclerosis and occlusive coronary artery disease," Cell Metabolism, vol.
(38,39) Three AKT isoforms (AKT1
, AKT2 and AKT3) can mediate downstream events through PI3K.
Lutchman et al., "The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
," EMBO Journal, vol.
In EAT, there were increases in the insulin receptor ( IR) and IR substrate 2 ( IRS2) mRNA, but CE-induced increases in mRNA expression of IRS1, phosphoinositide-3-kinase, AKT1
, glucose transporters 1 and 4, and glycogen synthase 1 expression and decreased trends in mRNA expression of glycogen synthase kinase 3beta were not statistically significant.
Genetic inactivation of AKT1
, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Once activated by PI3K, Akt1
promotes cell cycle progression, inhibits apoptosis, induces protein synthesis, and triggers mTORC1--promoting cell growth via mitochondrial biogenesis and lipid synthesis [44,45].
A eles, podem-se acrescentar os resultados de um prestigioso estudo multicentrico europeu de 2008, que testou a relacao entre esquizofrenia e catorze dos principais nucleotideos unicos associados pela literatura (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1
, CHRNA7, COMT e ARVCF), nao encontrando relacao significativa para nenhum deles, o que per se relativiza a atratividade de Hipoteses Etiologicas Unificadas em geral (Sanders, et al., 2008).
Debido a que las aberraciones en Akt1
son mas frecuentes, Akt2 y Akt3 deben suplir diferentes funciones, generando, asi, una presion selectiva para aberraciones durante la genesis tumoral.
The MyoMouse is a mouse that has been genetically engineered to express the Akt1
Miransertib (ARQ 092) is an orally available, selective, pan-AKT (protein kinase B) inhibitor that potently inhibits AKT1
, 2 and 3 isoforms.
Lung cancer specimens were analyzed for AKT1
(NM_005163), BRAF (NM_004333), EGFR (NM_005228), ERBB2 (NM_004448), KRAS (NM_033360), NRAS (NM_002524), and PIK3CA (NM_006218) genes.