AKT1

A gene on chromosome 14q32.32|14q32.32 that encodes protein kinase B (PKB), a serine-threonine protein kinase that is rapidly and specifically activated by platelet-derived growth factor through phosphatidylinositol 3-kinase. PKB plays a key role in regulating cell survival, insulin signalling, angiogenesis, tumour formation and growth factor-induced neuronal survival. Activated AKT1 phosphorylates and inactivates components of the apoptotic machinery.

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Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.

Molekuler Tanida Yuksek Cozunurluklu Erime Yontemi ve Klinik Onemi/High Resolution Melting Method in Molecular Diagnostics and Their Clinical Importance

AKT1, ERK1/2, p38 MAPK, and NF-[kappa][beta]), resulting in cellular apoptosis.

Modulation of Hydrogen Peroxide-Induced Oxidative Stress in Human Neuronal Cells by Thymoquinone-Rich Fraction and Thymoquinone via Transcriptomic Regulation of Antioxidant and Apoptotic Signaling Genes

AKT1, AKT2, E2F1, IKK and NF-[kappa]B1) exhibited down-regulation.

Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells

A potassium channel, OsAKT1, homologous to the Arabidopsis root inward rectifier AKT1 was isolated.

COMPARATIVE STUDY OF GRAIN YIELD AND BIOCHEMICAL TRAITS OF DIFFERENT RICE VARIETIES GROWN UNDER SALINE AND NORMAL CONDITIONS

Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.

Clinical significance of EGFR and EGFRvIII expression in human esophageal carcinoma

In EAT, there were increases in the insulin receptor ( IR) and IR substrate 2 ( IRS2) mRNA, but CE-induced increases in mRNA expression of IRS1, phosphoinositide-3-kinase, AKT1, glucose transporters 1 and 4, and glycogen synthase 1 expression and decreased trends in mRNA expression of glycogen synthase kinase 3beta were not statistically significant.

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Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

New test may detect colon cancer in earlier stages

A eles, podem-se acrescentar os resultados de um prestigioso estudo multicentrico europeu de 2008, que testou a relacao entre esquizofrenia e catorze dos principais nucleotideos unicos associados pela literatura (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT e ARVCF), nao encontrando relacao significativa para nenhum deles, o que per se relativiza a atratividade de Hipoteses Etiologicas Unificadas em geral (Sanders, et al.

Esquizofrenia, genetica, epigenesis, ambiente: uma revisao sistematica das hipoteses etiologicas unificadas e do perfil genetica; e um novo algoritmo para o tratamento dos achados principais

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2:amplification of AKT1 in a primary human gastric adenocarcinoma.

Papel de la via fosfatidilinositol 3 kinasa (PI3K/Akt) en humanos

Within the AKT cascade, the response variable consisted of eight correlated gene expression values for each placenta--that is, two biopsies per placenta and four target genes (BDNF, AKT1, AKT2, and AKT3) measured in each biopsy.

In utero fine particle air pollution and placental expression of genes in the brain-derived neurotrophic factor signaling pathway: an environage birth cohort study

Combined effects of genetic variants of the PTEN, AKT1, MDM2 and p53 genes on the risk of nasopharyngeal carcinoma.

Phosphatase and Tensin Homologue Genetic Polymorphisms and their Interactions with Viral Mutations on the Risk of Hepatocellular Carcinoma

6] Human genes: EGFR, epidermal growth factor receptor; KRAS, Kirsten rat sarcoma viral oncogene homolog; TP53, tumor protein p53; NF2, neurofibromin 2 (merlin); AKT1, v-akt murine thymoma viral oncogene homolog 1; BRAF, B-Raf proto-oncogene, serine/ threonine kinase; NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; KMT2D, lysine (K)-specific methyltransferase 2D; NSD1, nuclear receptor binding SET domain protein 1; CREB3L1, cAMP responsive element binding protein 3-like 1; TPR, translocated promoter region, nuclear basket protein; TSC2, tuberous sclerosis 2.

Brain tumor mutations detected in cerebral spinal fluid

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