AKT1

A gene on chromosome 14q32.32|14q32.32 that encodes protein kinase B (PKB), a serine-threonine protein kinase that is rapidly and specifically activated by platelet-derived growth factor through phosphatidylinositol 3-kinase. PKB plays a key role in regulating cell survival, insulin signalling, angiogenesis, tumour formation and growth factor-induced neuronal survival. Activated AKT1 phosphorylates and inactivates components of the apoptotic machinery.

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Teer et al., "A mosaic activating mutation in AKT1 associated with the proteus syndrome," New England Journal of Medicine, vol.

Differential diagnoses of overgrowth syndromes: the most important clinical and radiological disease manifestations

Yu et al., "Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease," Cell Metabolism, vol.

Andrographolide inhibits nuclear factor-[kappa]B activation through JNK-Akt-p65 signaling cascade in tumor necrosis factor-[alpha]-stimulated vascular smooth muscle cells

(38,39) Three AKT isoforms (AKT1, AKT2 and AKT3) can mediate downstream events through PI3K.

Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells

Lutchman et al., "The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1," EMBO Journal, vol.

Dissecting major signaling pathways throughout the development of prostate cancer

In EAT, there were increases in the insulin receptor ( IR) and IR substrate 2 ( IRS2) mRNA, but CE-induced increases in mRNA expression of IRS1, phosphoinositide-3-kinase, AKT1, glucose transporters 1 and 4, and glycogen synthase 1 expression and decreased trends in mRNA expression of glycogen synthase kinase 3beta were not statistically significant.

Cinsulin

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

New test may detect colon cancer in earlier stages

Once activated by PI3K, Akt1 promotes cell cycle progression, inhibits apoptosis, induces protein synthesis, and triggers mTORC1--promoting cell growth via mitochondrial biogenesis and lipid synthesis [44,45].

Overcoming resistance in breast cancer

A eles, podem-se acrescentar os resultados de um prestigioso estudo multicentrico europeu de 2008, que testou a relacao entre esquizofrenia e catorze dos principais nucleotideos unicos associados pela literatura (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT e ARVCF), nao encontrando relacao significativa para nenhum deles, o que per se relativiza a atratividade de Hipoteses Etiologicas Unificadas em geral (Sanders, et al., 2008).

Esquizofrenia, genetica, epigenesis, ambiente: uma revisao sistematica das hipoteses etiologicas unificadas e do perfil genetica; e um novo algoritmo para o tratamento dos achados principais

Debido a que las aberraciones en Akt1 son mas frecuentes, Akt2 y Akt3 deben suplir diferentes funciones, generando, asi, una presion selectiva para aberraciones durante la genesis tumoral.

Papel de la via fosfatidilinositol 3 kinasa (PI3K/Akt) en humanos

The MyoMouse is a mouse that has been genetically engineered to express the Akt1 gene.

Nara Biosciences Inc. Inks License Agreement for MyoMouse Platform

Miransertib (ARQ 092) is an orally available, selective, pan-AKT (protein kinase B) inhibitor that potently inhibits AKT1, 2 and 3 isoforms.

ArQule Clinical Data Published on Miransertib in Proteus Syndrome

Lung cancer specimens were analyzed for AKT1 (NM_005163), BRAF (NM_004333), EGFR (NM_005228), ERBB2 (NM_004448), KRAS (NM_033360), NRAS (NM_002524), and PIK3CA (NM_006218) genes.

Clinical Validation of Coexisting Activating Mutations Within EGFR, Mitogen-Activated Protein Kinase, and Phosphatidylinositol 3-Kinase Pathways in Lung Cancers

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