AKAP8

A gene on chromosome 19p13.1 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of cAMP-dependent protein kinase A (PKA), confining the enzyme to discrete locations within the cell based on different targeting motifs. AKAP8 binds to the RII-alpha subunit of PKA, and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin.

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For example, Y53 of AKAP8 (O43823) is catalyzed by SRC and can be correctly assigned by our method but cannot be predicted by the existing tools.

A Novel Phosphorylation Site-Kinase Network-Based Method for the Accurate Prediction of Kinase-Substrate Relationships

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