AKAP1

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AKAP1

A gene on chromosome 17q21-q23 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds type-I and -II regulatory subunits of protein kinase A, anchoring them to the cytoplasmic face of the mitochondrial outer membrane. AKAP1 is thought to play a role in cAMP-dependent signal transduction and in directing RNA to a specific cellular compartment.
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At telophase stage, PP1 (a Ser/Thr phosphatase) is targeted to lamin B by A-kinase anchoring protein (AKAP149) which is a membrane bound PP1 binding protein (Fig.2(c)).
As already explained, under normal conditions PP1 is targeted to NE by AKAP149 at the end of mitosis and it induces lamin B assembly.
AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase.