AKAP10

AKAP10

A gene on chromosome 17p11.1 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of protein kinase A (PKA), confining the enzyme to discrete locations within the cell based on different targeting motifs. AKAP10 binds to both RI- and RII-alpha subunits of PKA; it also has an RGS (regulator of G protein-signalling) domain and thus might interact with G-alpha proteins, providing a link between the signalling machinery and the downstream kinase.
References in periodicals archive ?
17] Loniewska B, Clark JS, Kaczmarczyk M, Adler G, Binczak-Kuleta A, Kordek A, et al Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10.
When a 60-bp fragment of AKAP10 [A kinase (PRKA) anchor protein 10] was amplified for 35 cycles with 20 [micro]mol/L primers and 8 [micro]mol/L polymerase, no product was observed on gels at 2-3 mmol/L, minimal product at 4 mmol/L, and a large amount of specific product at 5-7 mmol/L Mg[Cl.
4] Human genes: KCNE1, potassium voltage-gated channel, Isk-related family, member 1; IL10RB, interleukin-10 receptor, [beta]; NQO1, NAD(P)H dehydrogenase, quinone 1; AKAP10, A kinase (PRKA)anchor protein 10.