AIM2

AIM2

A gene on chromosome 1q22 that encodes an IFN-gamma-induced tumour suppressor of the IFI20X/IFI16 family, which is thought to play a role in tumour regression and may control cell proliferation.
References in periodicals archive ?
The inflammasome are NLRP1, NLRP3, NLRC4 and AIM2 (Figure 1) which belongs to a different protein family (PYHIN).
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.
AIM2 es un receptor citosolico perteneciente a la familia de proteinas PYHIN, ya mencionada, que reconoce el ADN de doble banda derivado de virus y bacterias patogenas en el citoplasma de macrofagos infectados (18).
AIM2 protein levels in response to a Human Papillomavirus and the impact of infectious microbes in cervical cancer cell lines.
These CSCs were found to have significantly higher expressions of three antigens targeted by ICT-107--Her-2/neu, AIM2, and TRP-2--than the cells that make up the bulk of the tumour.
8] AIM2, second interviewee from a Moroccan Immigrant association.
They have discovered a protein called AIM2 that detect and reacts to dangerous cytoplasmic DNA produced by viral or microbial pathogens.
In a mouse model of IL-23-induced psoriasis, the inflammasome components NLRP3 and AIM2 were up-regulated and IL-1 was increased compared to control animals.
The contract consists of relying on the supply of pipes, fittings and special parts made of spheroidal cast iron PN16 for transport of drinking water, DN 700 mm, ex works and / or AIMAG warehouse and / or in areas provided by AIMAG, including For the realization of the AIM2.
Earlier reports have suggested that SFN inhibited caspase-1 cleavage and IL-1[beta] maturation for the NLRP1b, NLRP3, NAIP5/NLRC4, and AIM2 inflammasomes in immune cells [18].
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.