En los componentes de los inflamosomas, el mRNA de NLRP1, NLRP3, NLRC4, AIM2
, ASC, caspasa-1, IL-1[beta] e IL-18 fue cuantificado por RT-PCR en tiempo real a partir del CDNA utilizando el estuche comercial "Maxima sybr Green qPCR master mix" (Fermentas).
The venture is called AIM2
and has AI capabilities.
Such processes and initiatives include the officer-focused Assignment Interactive Module 2.0 (AIM2
), the enlisted Manner of Performance (MOP) tool, the new Academic Evaluation Report (AER), the Integrated Personnel and Pay System--Army (IPPS--A), and the proposed reforms of the Defense Officer Personnel Management Act (DOPMA) and Reserve Officer Personnel Management Act (ROPMA).
To date, several types of inflammasomes have been reported, such as NLRP1, NLRP3, and NLRC4, including the intracellular NOD-like receptor family and the absence in melanoma 2 (AIM2
) inflammasome .
Kang et al., "PKM2-dependent glycolysis promotes NLRP3 and AIM2
inflammasome activation," Nature Communications, vol.
Zhu et al., "Critical role for the DNA sensor AIM2
in stem cell proliferation and cancer," Cell, vol.
A gene called Aim2
, which encodes a "damage-and-danger" sensing protein, appeared particularly crucial: an initial bout of inflammation prompts a sustained increase in its expression.
The best-known ALRs, absent in melanoma 2 (AIM2
) and IFN-[gamma] inducible protein 16 (IFI16), function as intracellular immune sensors that detect microbial DNA.
Amongst several inflammasomes are interferon gamma-inducible protein 16 (IFI16), absent in melanoma 2 (AIM2
), apoptosis-associated speck-like protein containing a CARD (ACS), NLR-family apoptosis inhibitory protein (NAIP), NOD-like receptor-family CARD domain containing protein 4 (NLRC4), NLR family pyrin domain containing 1 (NLRP1), and NLRP3 [15, 16].
Thygesen et al., "Deficient NLRP3 and AIM2
inflammasome function in autoimmune NZB mice," The Journal of Immunology, vol.
Sensor protein can be formed by either members of the Nod-like receptor family (NLRP1, NLRP2, NLRP3, NLRC4, NLRP6, NLRP7, etc.) or the PYHIN family members AIM2
and IFI16 .