AURKB

(redirected from AIK2)

AURKB

A gene on chromosome 17p13.1 that encodes Aurora kinase B, which is involved in regulating many mitotic events. Aurora B is the catalytic component of the chromosomal passenger complex (CPC), which is critical for the correct progression through and completion of mitosis. It phosphorylates the CPC subunits BIRC5/survivin, CDCA8/borealin and INCENP, the last of which increases AURKB activity.
References in periodicals archive ?
The Aurora-B is encoded by the AURKB gene (also known as AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM1; STK12), mapped to chromosome 17p13.1, and consisting of 9 exons (Gene ID: 9212).