AIFM1

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AIFM1

A gene on chromosome Xq26.1 that encodes an oxidoreductase with both apoptotic and anti-apoptotic activity. During apoptosis, AIFM1 is
translocated from the mitochondria to the nucleus to act as a pro-apoptotic factor in a caspase-independent pathway; its anti-apoptotic activity occurs in mitochondria and is attributed to oxidoreductase. It plays a key role in caspase-independent pyknotic cell death in hydrogen-peroxide-exposed cells.

References in periodicals archive ?

In the renal cortex they confirmed differences in expression of apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), alpha-1-microglobulin/bikunin precursor (AMBP), apolipoprotein E (APOE), cluster of differentiation 36 (CD36), ephrin-B1 (EFNB1), NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 (NDUFAF1), peroxiredoxin 5 (PRDX5), REN, renin binding protein (RENBP), solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1), syntaxin 4 (STX4), and troponin T type 2 (cardiac) (TNNT2) mRNAs, and the miRNAs hsa-miR-21, hsa-miR-126, hsa-miR-181a, hsa-miR-196a, hsamiR-451, hsa-miR-638, and hsa-miR-663.

MicroRNA in diabetic nephropathy: renin angiotensin, AGE/RAGE, and oxidative stress pathway

DSW 600 upregulated expression of apoptosis- inducing factor, mitochondrion-associated 1 (Aifm1), DNA-damage- inducible, alpha (Gadd45a), myeloid cell leukemia sequence 1 (Mcl 1), and X-linked inhibitor of apoptosis (Xiap).