AIF1


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AIF1

A gene on chromosome 6p21.3 that encodes allograft inflammatory factor 1, an actin-binding, cytokine- and interferon-induced protein that regulates proliferation of vascular smooth muscle cells, resulting in an anti-inflammatory response to vessel wall trauma.

AIF1 activities
• Enhances lymphocyte migration and actin-bundling activity of LCP1.
• Plays a role in RAC signalling, phagocytosis and in vascular inflammation.
• Promotes proliferation of vascular smooth muscle cells and of T cells.
• May play a role in macrophage activation and function.
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References in periodicals archive ?
The results of present study suggest that AIF1 gene rs2269475 polymorphism is associated with RA development; however, has no influence on disease activity.
Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.
Allograft inflammatory factor-1 rs2269475 genotypes in rheumatoid arthritis patients and controls RA patients Control group p * (n=380) (n=378) n % n % AIF1 rs2269475 genotype CC 257 67.