AIF1


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AIF1

A gene on chromosome 6p21.3 that encodes allograft inflammatory factor 1, an actin-binding, cytokine- and interferon-induced protein that regulates proliferation of vascular smooth muscle cells, resulting in an anti-inflammatory response to vessel wall trauma.

AIF1 activities
• Enhances lymphocyte migration and actin-bundling activity of LCP1.
• Plays a role in RAC signalling, phagocytosis and in vascular inflammation.
• Promotes proliferation of vascular smooth muscle cells and of T cells.
• May play a role in macrophage activation and function.
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References in periodicals archive ?
In this study, we examined whether AIF1 gene rs2269475: C>T polymorphism is associated with RA development and disease activity.
Particular alleles in the genes for transforming growth factor-[beta] (TGF-[beta]), monocyte chemoattractant protein-1 (MCP-1), IL-1alpha, tumor necrosis factor, allograft inflammatory protein-1 (AIF1), and angiotensin converting enzyme (ACE) have been linked to disease susceptibility.
(33) El gen que codifica para NKp30 se encuentra en el cromosoma 6, en la region del MHC-II entre los genes para LTB y AIF1. (10,15,25,34) La porcion citoplasmatica de este receptor carece de dominios ITAM, por lo cual para la transmision de las senales activadoras NKp30 se asociacion con la cadena CD3z.
Because the older equilibrium GCM scenarios generally projected greater climate change (see UKMO in Table 2), they serve as useful proxies to illustrate the possible magnitude of vegetation change that may result from the upper range of the newly available SRES-based climate-change projections (i.e., AIF1, AIB or A2 scenarios in IPCC 2001a), which have not yet been combined with GVMs to explore the implications for vegetation change in North America.