AIF1

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AIF1

A gene on chromosome 6p21.3 that encodes allograft inflammatory factor 1, an actin-binding, cytokine- and interferon-induced protein that regulates proliferation of vascular smooth muscle cells, resulting in an anti-inflammatory response to vessel wall trauma.

AIF1 activities
• Enhances lymphocyte migration and actin-bundling activity of LCP1.
• Plays a role in RAC signalling, phagocytosis and in vascular inflammation.
• Promotes proliferation of vascular smooth muscle cells and of T cells.
• May play a role in macrophage activation and function.
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References in periodicals archive ?
1) AIF-1 is involved in the inflammatory response associated with transplant rejection and has documented expression in various human tissues and cells, such as macrophages and peripheral blood leukocytes.
Moreover they have demonstrated increased expression of AIF-1 in mononuclear cells of RA patients compared with healthy controls.
6) examined the expression of AIF-1 in synovial tissues and measured AIF-1 in synovial fluid derived from patients with either RA or osteoarthritis as well as assessed the proliferation of synovial cells and induction of interleukin 6 (IL-6) following AIF-1 stimulation.
AIF-1 is a cytokine playing the significant role in chronic inflammatory processes, especially those involving macrophages.
The deduced amino acid sequence of Sn- AIF-1 showed high homology with AIF-1 in vertebrates such as fish, mice, and humans; and in the case of invertebrates, the major degree of identity (55%) was with a predicted sequence of the purple sea urchin AIF-1, and 52% corresponded to a sponge.
KEY WORDS: Antarctica, sea urchin, Sterechinus neumayeri, coelomocytes, gene expression, AIF-1
purpuratus AIF-1 and other AIF family proteins (Table 1), indicating that Sn-AIF-1 is less hydrophobic.
On the other hand, AIF-1 contains a typical pattern of precursors of hormonally active peptide (-KR-KK-GKR-).