AIDSVAX


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AIDSVAX

A vaccine produced by VaxGen which failed to protect those receiving the vaccine from developing AIDS, although some data suggested that it may benefit African Americans. VaxGen has continued to expand the trials. The results of the Phase II trials were underwhelming, so VaxGen piggybacked it with the Aventis-Pasteur vaccine, ALVAC-HIV. Data from the combination vaccine, ALVAC-AIDSVAX B/E, has shown an efficacy ranging from 26 to 31% (N Engl J Med 2009; 361: 23, 2209-2220).
References in periodicals archive ?
Concurrently, the eligible participants in HVTN 114 will receive either another MVA62B boost, a combined boost of MVA62B and AIDSVAX B/E, or AIDSVAX B/E alone.
Un posible principio para la cura del VlH realizado en 2009 a mas de 16,000 personas (el mas grande en su tipo), fue la combinacion de 2 vacunas que de manera individual no resultaron viables: un virus aviar con 3 genes de VlH destinado a reparar el sistema inmune, y una version modificada de AIDSVAX como refuerzo.
Results from a recent vaccine trial in Thailand demonstrated preliminary efficacy of a combination ALVAC-HIV and AIDSVAX B/E vaccine regimen among a community-based sample consisting mostly of relatively low-risk heterosexuals (Rerks-Ngarm et al.
The decision to proceed with the study was highly controversial as a previous version of the AIDSVAX failed to show any benefit in two previous studies and the ALVAC was considered be insufficiently immunogenic to proceed to an efficacy trial [6].
The booster dose, AIDSVAX B/E, is a glycoprotein 120 vaccine.
AIDSVAX contains a genetically engineered version of a protein on HIV's surface.
The vaccines used during the trials were ALVAC, from Sanofi Pasteur, the vaccine division of French drugmaker Sanofi-Aventis and AIDSVAX, developed by VaxGen Inc.
The vaccine is a combination of Sanofi-Aventis ALVAC canary pox vaccine and HIV vaccine AIDSVAX, made by VaxGen, Reuters reported.
In 1998 clinical trials began for the AIDSVAX vaccine, and the U.
Racialized bio-medicine, generated difference: The possibility of racial differentials in the efficacy of AIDSVAX.