Starting cART while participating in an ART naive clinical trial, baseline CD4+T lymphocyte count (cells/[micro]L), baseline HIV viral load ([log.sub.10] copies/mL) and AIDS-defining disease
were also accessed.
She was diagnosed with HIV in 2009 when she presented with severe mucocutaneous Kaposi's sarcoma (KS) as her AIDS-defining disease
. She was pregnant at the time of her initial diagnosis, and received 4 cycles of bleomycin/vincristine chemotherapy after delivering a healthy term infant.
Throughout the trial, any mother whose CD4 count fell below 250 cells per [mu]l or who developed an AIDS-defining disease
was referred for treatment.
The delayed group experienced a shorter time to a primary clinical event, including AIDS-defining disease
and all types of tuberculosis.
One of the controversies in this field is the question of whether DVT in the patient infected with HIV should be considered an AIDS-defining disease
. Our approach is that it should be.
[less than or equal to] 3.4 (2.0-5.7) < 0.001 10 years) AIDS-defining disease
0.7 (0.5-1.0) 0.06 (vs.
The presence of high CD4 counts and of polyclonal lymphomas, and the absence of Epstein-Bar virus infection and of AIDS-defining disease
before diagnosis are associated with improved survival of these patients [2,10,11,16-19].
Whereas AIDS-defining diseases
pose a greater threat when the CD4 count falls below 200 cells/[mm.sup.3], non-AIDS diseases often threaten HIV-infected people at higher CD4 counts.
KS, he notes, is seen mostly in gay men, while "weight loss and tuberculosis predominate in intravenous drug users, and pneumonia and candidiasis are almost the only two of the 30 AIDS-defining diseases
that are diagnosed in hemophiliacs." 
The real question was: How many AIDS-defining diseases
were to be found in the HIV-negative cohort?
START aims to assess the impact of earlier ART not only on AIDS-defining diseases
, but also on cardiovascular, liver, and kidney disease and mortality from any cause.
They did not compare otherwise similar persons who differ only in HIV status, did not control effectively for drug use, and did not fully report the incidence of AIDS-defining diseases
in the HIV-negative men.