ATIC

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ATIC

A gene on chromosome 2q35 that encodes a bifunctional protein that catalyses the last two steps in purine biosynthesis.

Molecular pathology
ATIC mutation causes AICA-ribosiduria.
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References in periodicals archive ?
AICAR Histologically Improves Liver Inflammation and Fibrosis.
AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-[kappa]B Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats
AICAR and palmitate were purchased from Wako (Osaka, Japan).
Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK
Further, pretreatment of MSCs with the AMPK activator, AICAR, increased AMPK phosphorylation and decreased LC3-II levels in common with that in cells treated with hinokitiol alone (Figure 6(a)).
AMPK Activation Mediated by Hinokitiol Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells through Autophagy Flux
Antemortem injection of HAT inhibitor II diminished AICAR induced an increase in postmortem glycolysis.
Histone acetyltransferase inhibitors antagonize AMP-activated protein kinase in postmortem glycolysis
Li et al., "AMPK-dependent and independent effects of AICAR and compound C on T-cell responses," Oncotarget, vol.
Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1
(2000) Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro.
Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle
Alford, "Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism," Journal of Applied Physiology, vol.
A kinetic model of whole-body glucose metabolism with reference to the domestic dog (canis lupus familiaris)
A close association exists between AMPK activity and exercise intolerance, as evidenced by increased exercise capacity in animals chronically treated with the AMPK activator, AICAR (5-aminoimidazole-4-carboxamide-1-[beta]-D-ribofuranoside) [39], and the decrease in exercise tolerance in AMPK[beta]2, AMPK[beta]1[beta]2, and AMPK[alpha]2 knockdown or knockout mice [22,24, 32].
Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice
Frangioudakis et al., "AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats," Diabetes, vol.
Antidiabetic effect of methanolic extract from Berberis julianae schneid. via activation of AMP-activated protein kinase in type 2 diabetic mice
Hung et al., "Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats," PLoS ONE, vol.
Mitochondrial stress signaling promotes cellular adaptations
AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.
The impact of metformin use on recurrence and cancer-specific survival in clinically localized high-risk renal cell carcinoma
Similarly, various AMPK agonists, including the AMPK mimetic AICAR, block AMPK deactivation and prevent SW-induced GVBD in nemerteans, whereas co-adding cAMP elevators overrides such blockage and restores GVBD (Fig.
Oocyte maturation and fertilization in marine nemertean worms: using similar sorts of signaling pathways as in mammals, but often with differing results

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