ATIC

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ATIC

A gene on chromosome 2q35 that encodes a bifunctional protein that catalyses the last two steps in purine biosynthesis.

Molecular pathology
ATIC mutation causes AICA-ribosiduria.
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Antemortem injection of HAT inhibitor II diminished AICAR induced an increase in postmortem glycolysis.
2015) A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats.
AICAR normally works by activating the body's metabolic "master switch," an enzyme called AMPK that, among other things, influences muscle activity.
Drugs such as anti-diabetic drug Metformin and AICAR, used to combat obesity, can prevent the hepatitis C virus from replicating in the body, the study suggests.
Pretreatment with the AMPK pharmacological activator AICAR or transfection with a CA-AMPK plasmid led to a recovery effect on reduced neurite outgrowth induced by As, suggesting that blunted AMPK activation is responsible for the inhibitory effect of As.
Table 2 depicts representative examples of reactions that involve simple molecules to compounds of relatively higher complexity like AICAR, and it is evident that all the product molecules are entirely utilized--the main product progresses to the next step and the rest of the products are fed back into the network for other reactions.
Building on research that produced a genetically altered "marathon mouse" in 2004, scientists have shown that a drug called AICAR can boost the running endurance of mice by about 45 percent--exercise not required.
There is clear evidence that methotrexate treatment leads to AICAR accumulation.
Conversely, AMPK activation by AICAR reverses Ang II-mediated increased E3 ubiquitin ligases mRNA levels [93].
AMPK agonists, including AICAR (5-Aminoimidazole-4-carboxamide 1-[beta]-D-ribofuranoside) and metformin have been shown to promote glucose disposal in muscle (Sajan et al.
Professor Greg Florant, a biologist at the Colorado State University, discovered he could slowly release a molecule called AICAR into yellow-bellied marmots that activates a neurological pathway driving food intake and stimulates appetite.
It is of note that AICAR, a reference AMPK activator, induced a robust increase of its phosphorylation in our cellular setting.