ATIC

(redirected from AICAR)
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ATIC

A gene on chromosome 2q35 that encodes a bifunctional protein that catalyses the last two steps in purine biosynthesis.

Molecular pathology
ATIC mutation causes AICA-ribosiduria.
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References in periodicals archive ?
Antemortem injection of HAT inhibitor II diminished AICAR induced an increase in postmortem glycolysis.
Histone acetyltransferase inhibitors antagonize AMP-activated protein kinase in postmortem glycolysis
2015) A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats.
Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle
AICAR normally works by activating the body's metabolic "master switch," an enzyme called AMPK that, among other things, influences muscle activity.
'Couch potato pill' may combat heat stroke too
Drugs such as anti-diabetic drug Metformin and AICAR, used to combat obesity, can prevent the hepatitis C virus from replicating in the body, the study suggests.
Diabetes, obesity drugs may help treat hepatitis C
Pretreatment with the AMPK pharmacological activator AICAR or transfection with a CA-AMPK plasmid led to a recovery effect on reduced neurite outgrowth induced by As, suggesting that blunted AMPK activation is responsible for the inhibitory effect of As.
Arsenic inhabits neurite outgrowth by inhibiting the LKB1-AMPK signaling pathway
Table 2 depicts representative examples of reactions that involve simple molecules to compounds of relatively higher complexity like AICAR, and it is evident that all the product molecules are entirely utilized--the main product progresses to the next step and the rest of the products are fed back into the network for other reactions.
Analysis of the intermediary metabolism of a reductive chemoautotroph
Building on research that produced a genetically altered "marathon mouse" in 2004, scientists have shown that a drug called AICAR can boost the running endurance of mice by about 45 percent--exercise not required.
Take two and run farther in the morning: drugs improve muscular endurance in lab mice
There is clear evidence that methotrexate treatment leads to AICAR accumulation.
Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis
Conversely, AMPK activation by AICAR reverses Ang II-mediated increased E3 ubiquitin ligases mRNA levels [93].
Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences
AMPK agonists, including AICAR (5-Aminoimidazole-4-carboxamide 1-[beta]-D-ribofuranoside) and metformin have been shown to promote glucose disposal in muscle (Sajan et al.
Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: the relationship to AMPK activation
Professor Greg Florant, a biologist at the Colorado State University, discovered he could slowly release a molecule called AICAR into yellow-bellied marmots that activates a neurological pathway driving food intake and stimulates appetite.
Study on hibernating marmots may help understand obesity
It is of note that AICAR, a reference AMPK activator, induced a robust increase of its phosphorylation in our cellular setting.
Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity

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