NCOA3

(redirected from AIB1)
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NCOA3

A gene on chromosome 20q12 that encodes a nuclear receptor coactivator, which interacts with nuclear hormone receptors to enhance transcription. NCOA3 has histone acetyltransferase activity and recruits other proteins, forming a multi-unit coactivation complex. It first appears in the cytoplasm but is translocated into the nucleus upon phosphorylation.
References in periodicals archive ?
In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity.
Brown, "Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland," Cancer Research, vol.
Kalofonos, "Estrogen receptor [alpha]/[beta], AIB1, and TIF2 in colorectal carcinogenesis: do coregulators have prognostic significance?" International Journal of Colorectal Disease, vol.