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antihemophilic factor (factor VIII, one of the coagulation factors).
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

antihemophilic factor (AHF, factor VIII)

Advate, Alphanate, Hemofil M, Koate-DVI, Kogenate FS, Monarc-M, Monoclate-P, Recombinate, ReFacto

Pharmacologic class: Hemostatic

Therapeutic class: Antihemophilic

Pregnancy risk category C

FDA Box Warning

• Drug is made from human plasma and may contain infectious agents. Plasma donor screening, testing, and inactivation or removal methods reduce this risk.


Promotes conversion of prothrombin to thrombin (necessary for hemostasis and blood clotting). Also replaces missing or deficient clotting factors, thereby controlling or preventing bleeding.


I.V. injection: 250, 500, 1,000, or 1,500 international units/vial in numerous preparations

Indications and dosages

Spontaneous hemorrhage in patients with hemophilia A (factor VIII deficiency)

Adults and children: Dosage is highly individualized, calculated as follows: AHF required (international units) equals weight (kg) multiplied by desired factor VIII increase (% of normal) multiplied by 0.5.

To control bleeding, desired factor VIII level is 20% to 40% of normal for minor hemorrhage; 30% to 60% of normal for moderate hemorrhage; or 60% to 100% of normal for severe hemorrhage. To prevent spontaneous hemorrhage, desired factor VIII level is 5% of normal.


• Hypersensitivity to drug or to mouse, hamster, or bovine protein


Use cautiously in:

• hepatic disease

• blood types A, B, and AB

• patients receiving factor VIII inhibitors

• pregnant patients

• neonates and infants.


• Before giving, verify that patient has no history of hypersensitivity to drug or to mouse, hamster, or bovine protein.

• Follow prescriber's instructions regarding hepatitis B prophylaxis before starting therapy.

• Refrigerate concentrate until ready to reconstitute drug; then warm to room temperature before mixing.

• Roll bottle gently between hands until drug is well-mixed.

• Give a single dose over 5 to 10 minutes at rate of 2 to 10 ml/minute, as appropriate.

• After drug is reconstituted, don't refrigerate, shake, or store near heat.

• Don't mix with other I.V. solutions.

• Use plastic (not glass) syringe and filter.

Adverse reactions

CNS: headache; lethargy; fatigue; dizziness; jitteriness; drowsiness; depersonalization; tingling in arms, ears, and face

CV: chest tightness, angina pectoris, tachycardia, slight hypotension, thrombosis

EENT: blurred or abnormal vision, eye disorder, otitis media, epistaxis, rhinitis, sore throat

GI: nausea, vomiting, diarrhea, constipation, stomachache, abdominal pain, gastroenteritis, anorexia,

Hematologic: forehead bruises, increased bleeding tendency, thrombocytopenia, hemolytic anemia, intravascular hemolysis, hyperfibrinogenemia

Hepatic: hepatitis B transmission Musculoskeletal: myalgia, muscle weakness, bone pain, finger pain

Respiratory: dyspnea, coughing, wheezing, bronchospasm

Skin: rash, acne, flushing, diaphoresis, urticaria

Other: taste changes, allergic reaction, fever, chills, cold feet, cold sensations, infected hematoma, stinging at injection site, anaphylaxis, human immunodeficiency virus transmission


Drug-diagnostic tests. Bilirubin, creatine kinase: increased levels

Hemoglobin, platelets: decreased values

Patient monitoring

Monitor for signs and symptoms of anaphylaxis and hemolysis.

Watch for bleeding tendency and hemorrhaging.

• Check vital signs regularly.

• Monitor CBC and coagulation studies.

Assess for severe headache (may indicate intracranial hemorrhage).

Patient teaching

Tell patient to immediately report signs and symptoms of allergic response or bleeding tendency.

• Caution patient not to use aspirin during therapy.

• Instruct patient to contact prescriber if drug becomes less effective.

• Tell patient to report signs or symptoms of hepatitis B.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and vision.

• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.

• Notify patient that he'll undergo regular blood testing during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


Abbreviation for antihemophilic factor A.
Farlex Partner Medical Dictionary © Farlex 2012


antihemophilic factor
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Abbreviation for:
accelerated hyperfractionation
acute heart failure
acute hepatic failure
American Health Foundation
American Hospital Formulary
anterior heart field
antihemophilic factor (see there)
Argentine haemorrhagic fever
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Abbreviation for antihemophilic factor A.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
"The one million lives under AHF's care actually translates to many millions and many generations, if we consider the impact on the families who would have otherwise lost earning productive individuals, parents losing children or children becoming orphans," said Dr.
However, only four published investigations have assessed the clinical approach to AHF in the ED.[sup][4],[5],[6],[7] Regarding the current guidelines,[sup][2],[8],[9] these four studies have indicated that AHF patients receive inadequate therapy in the ED.[sup][4],[5],[6],[7] In addition, information on long-term outcomes of these cohorts is limited.[sup][4],[5],[6],[7] To improve the practice and outcomes of AHF in ED care, data on the initial characteristics, treatments, and outcomes of AHF patients are needed,[sup][10] particularly in China where previous data have been unavailable.
One important question AHF continually seeks to answer is: Who attends its health fairs?
Oman CARE was a prospective, hospital-based, multicenter registry of patients admitted with the diagnosis of AHF to 12 hospitals in Oman.
The billboards were first seen last month in Los Angeles, where the nonprofit is based, and will soon be coming to New York City subway platforms, AHF told International Business Times.
The steps for the induction were initiated during a visit to Bahrain by AHF CEO and FIH-head of international relations, Tayyab Ikram, who met with Bahrain Olympic Committee (BOC) officials and presented an invitation to the Bahrain Hockey Association (BHA), the only recognised hockey body in the kingdom, to become a member of the FIH and AHF.
In North America, patients with decompensated AHF are given loop diuretics as an essential component of therapy, [2] yet there are few randomised prospective data to guide their use.
The AIDS Healthcare Foundation (AHF) has released its latest music video parody, Downtown Funk, a high-energy, professionally-produced music video that promotes STD awareness and safer-sex inspired by Uptown Funk, the internationally chart-topping song recorded by British producer Mark Ronson featuring Bruno Mars.
Blackburn, United Kingdom, June 07, 2015 --(PR.com)-- Registrations are now open for the 24|7 Home Rescue Football Festival on June 13th, hosted by community-based children's football initiative AHF FC.
The finance secured by the housing association will be drawn down next month and was accessed through Affordable Housing Finance (AHF), a subsidiary of UK Government backed The Housing Finance Corporation (THFC).
Tsow-Tun Le Lum used the last of its funding from AHF in December 2013.