DAX1

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DAX1

A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.

Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
References in periodicals archive ?
Our Agency and our healthcare partners at Central Maine Medical Center and other regional hospitals are excited about our ability to successfully manage care in a home setting for individuals with chronic medical conditions such as heart failure," said Julie Shackley, AHCH President & CEO.
In November 2005, AHCH opened Maine's first inpatient hospice facility.
More information about AHCH can be found at the Agency's web site, www.