AHR

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AHR

A gene on 7p15 that encodes aryl hydrocarbon receptor, a ligand-activated transcription factor involved in cell cycle regulation and in regulating biological responses to planar xenobiotic halogenated aromatic hydrocarbons.
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Bradfield, "The AH-receptor: genetics, structure and function," Pharmacogenetics, vol.
Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants
Bradfield, "Tissue specific expression of the rat Ah-receptor and ARNT mRNAs," Nucleic Acids Research, vol.
The aryl-hydrocarbon receptor protein interaction network (AHR-PIN) as identified by tandem affinity purification (TAP) and mass spectrometry
The model Ah-receptor agonist beta-naphthoflavone inhibits aflatoxin B-1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes.
Comparative chronic liver toxicity of benzo[a]pyrene in two populations of the Atlantic killifish (Fundulus heteroclitus) with different exposure histories
Work in a number of labs, including Bradfield's, suggests that the Ah-receptor protein traces evolutionarily to sensory systems in bacteria.
The Ah-receptor protein contains a region characterized by a pattern of repeating amino acids, called the PAS domain.
However, Safe's studies now indicate that when the Ah-receptor lock is keyless, it will link up with another protein, known as Arnt.
The most unexpected dividends of Ah-receptor understanding may emerge in medicine.
Redefining Dioxins
A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine.
Direct assessment of cumulative aryl hydrocarbon receptor agonist activity in sera from experimentally exposed mice and environmentally exposed humans
Polybrominated diphenyl ethers (PBDEs) as Ah-receptor agonists and antagonists.
In Vitro Estrogenicity of Polybrominated Diphenyl Ethers, Hydroxylated PBDEs, and Polybrominated Bisphenol A Compounds

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