EIF2C4

(redirected from AGO4)

EIF2C4

A gene on chromosome 1p34 that encodes a protein required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC), binding to short RNAs, such as microRNAs or short interfering RNAs, and repressing the translation of mRNAs complementary to them. EIF2C3 lacks endonuclease activity and does not appear to cleave target mRNAs; it interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.

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REQUIREMENT OF RESEARCH AS A LEARNING TOOL IN MEDICAL EDUCATION - LESS IS MORE

The complex binds to siRNA by PAZ domain of AGO4 protein and is directed to the homologous DNA sequence for gene silencing at transcriptional level (TGS).

Epigenetic dynamics: role of epimarks and underlying machinery in plants exposed to abiotic stress

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