EIF2C4

(redirected from AGO4)

EIF2C4

A gene on chromosome 1p34 that encodes a protein required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC), binding to short RNAs, such as microRNAs or short interfering RNAs, and repressing the translation of mRNAs complementary to them. EIF2C3 lacks endonuclease activity and does not appear to cleave target mRNAs; it interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.
References in periodicals archive ?
Por ejemplo, en Arabidopsis thaliana, mutantes de AGO1 tienen afectaciones en las rutas de silenciamiento de ARN citoplasmatico y miRNA, y mutantes de AGO4 presentan problemas con el silenciamiento de la cromatina.