EIF2C2

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EIF2C2

A gene on chromosome 8q24 that encodes a protein required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC), binding to short RNAs, such as microRNAs or short interfering RNAs, and represseing the translation of mRNAs complementary to them. EIF2C2 lacks endonuclease activity and does not appear to cleave target mRNAs. It is required for transcriptional gene silencing of promoter regions which are complementary to bound short anti-gene RNA through inhibition of translation, independent of endonuclease activity.
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For example, biogenesis of miR-451 uses AGO2 instead of Dicer to form an AGO-cleaved pre-miR-451 (ac-pre-miR-451), which is trimmed down by a poly(A)-specific ribonuclease (PARN) to form the mature miR-451 (5).
They may interfere with the transcription of pri-miRNAs by targeting miRNA encoding genes, by inhibiting processing of pri-miRNAs by Dicer, and binding to the AGO2 protein to form an active RISC or by blocking the interaction between RISC and the target mRNA.
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
Pre-miRNAs can be attached to MVBs or other RNA-binding proteins (NPM1, AGO2, or HDL); after fusion with the plasma membrane, circulating miRNAs enter the bloodstream.
Asi, la proteina AGO2 de Drosophila melanogaster une siRNA por medio de su dominio PAZ (siglas del ingles piwi-argonaute-zwille), y esta en el complejo ribonucleasa RISC (<<complejo de silenciamiento inducido por ARN>>, del ingles RNA-induced silencing complex) que corta el ARNm diana (Hammond et al.
Moreover, seven SNPs in the 5 genes (DNMT3L, AGO1, AGO2, HDAC5, and PRKAG3) were non-significantly associated with all of the beef carcass and quality traits in the Snow Dragon beef population.
These derived from viral dsRNA replication-intermediates, incorporated into AGO2, were eliminated in Dcr knockout cells, and decreased in abundance upon cell differentiation.
Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma.
AGO2, GEMIN3, and GEMIN4 then interact with miRNA to form a ribonucleoprotein, which guides the miRNA into the RNA-induced silencing complex (RISC), where the miRNA strand anneals to the 3' untranslated regions (UTRs) of target mRNAs, promoting translational repression or mRNA degradation.
72) identified 2 small compounds that were able to target Dicer or inhibit the function of AGO2.