EIF2C1

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EIF2C1

A gene on chromosome 1p34.3 that encodes a protein required for RNA-mediated gene silencing, binding to short RNAs, such as microRNAs or short interfering RNAs, and repressing the translation of mRNAs complementary to them. EIF2C1 lacks endonuclease activity and does not appear to cleave target mRNAs. It is required for transcriptional gene silencing of promoter regions which are complementary to bound short anti-gene RNA.
References in periodicals archive ?
Moreover, seven SNPs in the 5 genes (DNMT3L, AGO1, AGO2, HDAC5, and PRKAG3) were non-significantly associated with all of the beef carcass and quality traits in the Snow Dragon beef population.
Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma.
This miRNA has been reported to target AGO1 protein, an integral part of the RISC complex and miRNA biogenesis process [14].
AGO1 is an essential component of the RISC complex necessary for the silencing of target mRNAs by miRNAs [2].
Por ejemplo, en Arabidopsis thaliana, mutantes de AGO1 tienen afectaciones en las rutas de silenciamiento de ARN citoplasmatico y miRNA, y mutantes de AGO4 presentan problemas con el silenciamiento de la cromatina.
Algunas proteinas, por ejemplo AGO1 y zwille (AGO10), actuan en mas de una ruta.
However, several lines of recent evidence, including from the host laboratory, suggest the existence of as yet unidentified functions for AGO1 in the nucleus; conclusive evidence for nuclear PTGS was, moreover, recently obtained in soybean.
1) analyse the nature of sRNA bound to nuclear AGO1 and identify their origin and targets;
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