AGGF1

AGGF1

A gene on chromosome 5q13.3 that encodes an FHA- and G patch domain-containing protein, which promotes angiogenesis and endothelial cell proliferation.

Molecular pathology
Defects in AGGF1 are a cause of Klippel-Trenaunay syndrome (OMIM:149000).
References in periodicals archive ?
VG5Q VG5Q, also known as AGGF1, is associated with Klippel-Trenaunay syndrome (KTS), a congenital vascular morphogenesis pathology.
(8.) Hu Y, Li L, Seidelmann SB, Timur AA, Shen PH, Driscoll DJ, Wang QK: Identification of association of common AGGF1 variants with susceptibility for Klippel Trenaunay syndrome using the structure association program.
Similar results were obtained with AGGF1 (angiogenic factor with G patch and FHA domains 1), a relatively newly isolated angiogenic factor that significantly reduced the ambulatory impairment associated with limb ischemia (6).