AFF3

AFF3

A gene on chromosome 2q11.2-q12 that encodes a tissue-restricted nuclear transcriptional activator preferentially expressed in lymphoid tissue, which may function in lymphoid development and oncogenesis.

Molecular pathology
In some ALL patients, AFF3 is fused to the gene for MLL.
References in periodicals archive ?
Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population.
The AFF gene family consists of AFF1 [also known as ALL1-fused gene from chromosome 4 (AF4)], AFF2 [also known as fragile X mental retardation 2 (FMR2)], AFF3 [also known as lymphoid nuclear protein related to AF4 (LAF4)], and AFF4 [also known as ALL1-fused gene from 5q31 (AF5q31) or major CDK9 elongation factor associated-protein (MCEF)] (21).
Based on the above-mentioned background, our study was inspired by these facts: the shared genetic architecture of RA and SLE (8-10); AFF1 and AFF3 belonging to the same genetic family (21); the success of replicating the association of AFF3 with SLE by targeting polymorphism related to RA (18); and the potential biological function of AFF1 in lymphocyte development (11,23-25).
Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
Items Aff3, Aff2, and Aff1 were related to the fourth dimension, Affection which explained a variance of 13.372 percent.