FABP4

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FABP4

A gene on chromosome 8q21 that encodes a lipid transport protein in adipocytes which plays a role in intracellular transport of long-chain fatty acids and retinoic acids, delivering them to their cognate receptors in the nucleus.
References in periodicals archive ?
There was no relationship with the number of previous pregnancies or deliveries or any other variable in mothers or newborns, nor with AFABP, EFABP, or leptin milk concentrations.
Mean (SE) AFABP breast milk concentrations (n = 57) were 26.7 (4.4) [micro]g/L, range 1.2 to 137.0 [micro]g/L.
There was a strong positive correlation with both AFABP (r = 0.482, P = 0.0001) and EFABP (r = 0.354, P = 0.007) but no correlation with adiponectin (r = -0.442, P = 0.744) or leptin (r = 0.206, P = 0.152).
Moreover, there were similar appreciable Correlations found, as mentioned above (AFABP vs EFABP, r = 0.471, P = 0.0002; EFABP vs birth weight, r = 0.289, P = 0.029; and leptin vs body weight before pregnancy, r = 0.418, P = 0.003; at the time of delivery, r = 0.410, P = 0.003; BMI before pregnancy, r = 0.513, P = 0.0001; and at the time of delivery, r = 0.487, P = 0.0003).
We found no relationship between adiponectin, AFABP, EFABP, or leptin and age, body height of mothers, or ponderal index of newborns.
We demonstrated, for the first time, the presence of adiponectin, AFABP, and EFABP in human breast milk.
The stoichiometry of AFABP:EFABP in breast milk was 1.5:1 in our study, which is very different from adipose tissue and surprisingly similar to the stoichiometry found in macrophages (36).