anadamide

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anadamide

(an-ad'a-mīd),
Endogenous ligand for the cannabinoid receptor.

anadamide

An endogenous cannabinoid neurotransmitter, which is synthesised from N-arachidonoyl phosphatidylethanolamine and degraded by fatty acid amide hydrolase. Anadamide has CNS effects when it binds to CB1 cannabinoid receptor, and peripheral effects when it binds to CB2. It acts as an endogenous ligand for vanilloid receptors, which transduce acute and inflammatory pain signals, by activating protein kinase C. It also impairs working memory, is important for implantation of early embryos at the blastocyst stage and appears to be involved in regulating feeding behaviour and neural generation of motivation and pain.
References in periodicals archive ?
In order to optimize the AEA suitable for high-altitude area, the surface tension and foam capacity of AEA under different air pressures are compared.
Internationally, AEA has gained respect in the global standards effort.
It should pointed out that although the radioligand [3.sup.[H]]-CP55.940 is able to bind with similar affinity to both CB1 and CB2 receptors, AEA shows a slightly more affinity for CB1R.
Then the cells were assigned into six groups, including control, AEA, [H.sub.2][O.sub.2], AEA + [H.sub.2][O.sub.2], AM251 + AEA + [H.sub.2][O.sub.2], and AM251 + [H.sub.2][O.sub.2] groups.
Together with Newmark Grubb Knight Frank, AEA tapped Kostow Greenwood Architects, known for their expertise in studio and theater design, to oversee the design and construction of the project.
He testified against Liddle last year, was ordered to pay more than $6 million restitution to AEA and was sentenced to two years in prison.
Following AEA's recommendations, the Legislature approved 208 Rounds 1-5 renewable energy projects totaling $202.5 million.
AEA said: "The board has been unable to achieve a long-term solution to the existing levels of net debt and the significant ongoing funding costs of the group's retirement benefit obligations.
Even though previous studies have shown that ACA isolates from ginger exhibited anti-tumor properties against a wide variety of cancers, there have been no reports thus far on the cytotoxic and apoptotic effects of the closely related 1'S-1'-aceotxyeugenoI acetate (AEA) (Fig.
The Montgomery Advertiser reported that campaign finance reports show the sponsor of the ads, True Republican PAC, received most of its funding from PACs heavily financed by AEA.
AEA Technology PLC (AEA Technology) (AAT.LN), an energy and climate change consultancy, has received a contract from United States Department of Energy.
The Army Engineer Association (AEA) is evolving and adapting to change, just as our units and leaders are meeting today's challenges.