anadamide

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anadamide

(an-ad'a-mīd),
Endogenous ligand for the cannabinoid receptor.

anadamide

An endogenous cannabinoid neurotransmitter, which is synthesised from N-arachidonoyl phosphatidylethanolamine and degraded by fatty acid amide hydrolase. Anadamide has CNS effects when it binds to CB1 cannabinoid receptor, and peripheral effects when it binds to CB2. It acts as an endogenous ligand for vanilloid receptors, which transduce acute and inflammatory pain signals, by activating protein kinase C. It also impairs working memory, is important for implantation of early embryos at the blastocyst stage and appears to be involved in regulating feeding behaviour and neural generation of motivation and pain.
References in periodicals archive ?
401(k) plan assets should be used to ensure that a bypass trust will fully use the AEA.
AEA did laud the state for allocating money to decrease the size of K-3 classes, and for making other improvements to the business climate by curtailing so-called frivolous lawsuits, which are filed when a company's stock goes down.
Garcia, Chairman and CEO respectively of AEA Investors, said, "Bill brings much to our enterprise, including strong relationships throughout the Asia region, strategic insight and business acumen, and a keen eye for opportunities that will benefit investors.