PDE8B

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PDE8B

A gene on chromosome 5q13.3 that encodes a cAMP-specific cyclic nucleotide phosphodiesterase, which hydrolyses the second messenger cAMP to AMP and thus plays a role in regulating physiological processes.

Molecular pathology
PDE8B mutations are linked to autosomal dominant striatal degeneration.
References in periodicals archive ?
However, those with AdSD and EVT who are in good health and have an ideal body mass index (BMI) may need a higher dose for maximum effect.
In general, AdSD responds better to botulinum toxin injections than AbSD.
A more permanent alternative treatment for AdSD is selective laryngeal adductor denervation (SLAD) or denervation-reinnervation (SLAD-R) surgery.
(40) AdsD, SPD-PV-Ostbiiro 0362 I, unpag., Leipzig, 5 October 1949.
(47) "Erganzungsbericht zu Bericht 1-327," 9 May 1951 (AdsD, SPD-PV-Ostburo 0361 II, unpag.).
Gorlitz" (AdsD, SPD-PV- Ostburo 0434 b, 17.6.1953 II Berichte, unpag.).
(16) Informe de Dingels sobre la visita de Llopis a la RFA, 8.9.1965, AdsD, Nachlass Fritz Erler 154.
(17) Tierno a Erler, 20.4.1965 y 27.6.1965, AdsD, Nachlass Fritz Erler 154.
(23) Vease la correspondencia entre Brandt y Otto Brenner, presidente del sindicato IG Metall, 13.3.1968 y 19.3.1968, AdsD, SPD-PV 10513.
(35) Nota de Hans-Eberhard Dingels, Director de la oficina de Relaciones Internacionales del SPD, sobre la reunion del Buro de la IS en Londres el 10 de septiembre de 1969, 16.9.1969, AdsD, WBA, A 11.4, 50.
In this case, the Active Duty Start Date (ADSD) is before the Active Commissioning Base Date (ACBD).
CWOs--Similar to LDOs in that the ADSD is used to calculate statutory retirement.