ADRB2


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ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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Quantitative RT-PCR (qPCR) was conducted to analyze expression of ADRB2 with a CFX-96 RT-PCR detection system (BioRad, Hercules, CA, USA).
It seems reasonable to incorporate 2 bulges for haplotyping of a 3-loci block, as shown with the ADRB2 20/ 46/79 probe, because only 4 haplotypes have been described at this locus.
We first demonstrated the reliability of our BAMPER method on three SNPs (rs3918242 for the gelatinase B gene, rs1346044 for the WRN gene, and rs1042718 for the ADRB2 gene), using hundreds of purified genomic DNA study samples.
For the genes NQO1, TNFA, TLR4, and ADRB2, we selected tag single-nucleotide polymorphisms (SNPs) in the gene region, 10 kb upstream from the 5' untranslated region (UTR), and 10 kb downstream from 3' UTR.
Stimulation of ADRB2 by catecholamines or synthetic therapeutic agonists promotes physiologic processes as varied as smooth muscle relaxation and lipolysis.