ADRB2


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ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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Furthermore, only case-control studies which had evaluated the association between asthma and ADRb2 polymorphism at codon 16(Arg16Gly) and codon 27(Glu27Gln) or one of these were included in this meta-analysis.
The horse ADRB2 transcript was analyzed by real-time polymerase chain reaction (RT-PCR) amplification.
We followed the STREGA (Strengthening the REporting of Genetic Association) guidelines to review the methods and results of studies reporting on the influence of ADRB2 Arg16Gly polymorphism on the pulmonary function response of ICS and LABAs treatment of asthma patients.
An environmental epigenetic study of ADRB2 5'-UTR methylation and childhood asthma severity.
In our research, we genotyped six SNP loci from the five candidate genes (IL13, IL4, IL4RA, MS4A2, ADRB2) in Mauritian Indian and Chinese Han populations in order to determine their association with asthma.
The probes with longer template omissions of 13-73 nt were designed for multiplex genotyping of the beta hemoglobin gene (HBB) (2) or haplotyping of the beta 2 adrenergic receptor (ADRB2) or of the WIAF 1537-1538 markers on chromosome 21 (1, 17)].
Association of persistent bronchial hyperresponsiveness with [[beta].sub.2]-adrenoceptor (ADRB2) haplotypes.
also reported that AT1R is directly interacted with [beta]2-adrenergic receptor (ADRB2) via heterodimerization [21].
The impact of tagged single-nucleotide polymorphisms (tagSNPs) and inferred haplotypes in 12 candidate genes (ACE, ADRB2, AGT, AGTR1, ALOX15, EDN1, GRK4, PTGS1, PTGS2, TLR4, VEGFA, and VEGFB) on the relationship between residential proximity to major roadways and LVM was analyzed using multiple linear regression, adjusting for multiple potential confounders.
The two genotypes (CCArgArg and CCTrpArg) of [[beta].sub.2]-adrenergic receptor gene (ADRB2) and [[beta].sub.3]-adrenergic receptor gene (ADRB3) were separated into the risk and protective genotype groups (p<0.05) in spite of their corresponding initial phenotypic means (p>0.05).
For example, a fragment of the adrenergic [[beta].sub.2] receptor gene (ADRB2) was first amplified as a 238-bp PCR product from purified genomic DNA (10 zmol), from 0.5 [micro]L of blood (containing 7.5-15 zmol of genomic DNA), and from 0.5-0.75 [micro]L of blood dried on the paper (containing 7.5-23 zmol of genomic DNA) by PCR (primers, 5'-AGC CTG CTG ACC AAG AAT AAG G-3' and 5'-CCC TGG AGT AGA CGA AGA CCA T-3').