ADRA2C

ADRA2C

A gene on chromosome 2p13-q13 that encodes alpha-2C-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS. ADRA2C is required for presynaptic control of transmitter release from sympathetic nerves in the heart and central noradrenergic neurons.
References in periodicals archive ?
The [AC.sub.50] values for amitraz for [alpha]-2A and [alpha]-2b adrenergic receptors were 0.05-1.6 [micro]M (ADRA2A, Adra2a, Adra2b), but this was not the case for other adrenergic receptor subtypes [[alpha]-2C (ADRA2C), [beta]-1 (ADRBI), [beta]-2 (ADRB2), P-3 (ADRB3)].
Common deletion in [alpha]2C-adrenergic receptor gene, ADRA2C (ADRA2C Del 322-325), results in the loss of four amino-acids.
[39] Among NE system genes, researchers have primarily focused on the noradrenaline transporter (NET1/SLC6A2) and on the adrenergic alpha receptors 2A and 2C (ADRA2A and ADRA2C).
En el sistema noradrenergico, los receptores ADRA2A, ADRA2C y ADRA1C, y el transportador de norepinefrina; en el sistema serotoninergico, los receptores de serotonina HTR1B y HTR2A, el transportador de serotonina y la triptofano hidroxilasa (Acosta, 2007).
Finalmente, en una serie de investigaciones interesantes se encontro que, cuando las poblaciones estudiadas se estratificaron por el genotipo Arg389Gly del gen del receptor adrenergico beta-1 (ADRB1) y el genotipo Ins/Del del gen ADRA2C (codifica un subtipo del receptor adrenergico [beta]-2), los pacientes homocigotos Arg389Arg o Ins/Ins tuvieron reduccion significativa de las tasas de hospitalizacion y mortalidad, en comparacion con los no portadores de estos alelos.
HTR2C, CHRM2, ADRA2B, HTR6, HTR5A, ADRA2C, HTR7, DRD2, and DRD4; SLC6A4, ADRA1A, HTR1A, ADRA1B, HTR2A, and DRD1; OPRL1, CHRM5, CHRM1, ADRB1, ADRA2A, and HRH1; and CHRM4, CHRM3, KCNH2, SLC6A4, CYP2D6, SCN1A: four clusters of neuronal GPCRs (G-proteincoupled receptors: adrenergic, cholinergic, histamine, and serotonin receptors).