ADRA2C

ADRA2C

A gene on chromosome 2p13-q13 that encodes alpha-2C-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS. ADRA2C is required for presynaptic control of transmitter release from sympathetic nerves in the heart and central noradrenergic neurons.
References in periodicals archive ?
Common deletion in [alpha]2C-adrenergic receptor gene, ADRA2C (ADRA2C Del 322-325), results in the loss of four amino-acids.
52, 53] On the other hand, Guan [36] reported a significant association between ADHD-C and the rs7682295 of ADRA2C (p<0.
En el sistema noradrenergico, los receptores ADRA2A, ADRA2C y ADRA1C, y el transportador de norepinefrina; en el sistema serotoninergico, los receptores de serotonina HTR1B y HTR2A, el transportador de serotonina y la triptofano hidroxilasa (Acosta, 2007).
Finalmente, en una serie de investigaciones interesantes se encontro que, cuando las poblaciones estudiadas se estratificaron por el genotipo Arg389Gly del gen del receptor adrenergico beta-1 (ADRB1) y el genotipo Ins/Del del gen ADRA2C (codifica un subtipo del receptor adrenergico [beta]-2), los pacientes homocigotos Arg389Arg o Ins/Ins tuvieron reduccion significativa de las tasas de hospitalizacion y mortalidad, en comparacion con los no portadores de estos alelos.