ADPKD


Also found in: Acronyms.

ADPKD

 
autosomal dominant polycystic kidney disease.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

autosomal dominant polycystic kidney disease

A common (1:400–1:1000) autosomal dominant condition (OMIM:173910), which causes 6–9% of end-stage renal disease in developed countries. ADPKD first appears in adults with upper quadrant tenderness; extrarenal disease is due to defective extracellular matrix, with hepatic cysts, diverticulosis, berry and abdominal aneurysms, annuloaortic ectasia and valvular regurgitation.

Clinical findings
Acute or subacute onset of azotaemia and hypertension, due to increased activity of the renin-angiotensin-aldosterone (RAA) system, possibly related to the ischaemic pressure induced by the expanding cysts.

Lab
Anaemia, increased ESR, increased WBCs.
 
Diagnosis
Ultrasonography.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ADPKD

Autosomal dominant polycystic kidney disease, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
La ADPKD es la enfermedad renal hereditaria mas frecuente y la causa de ERC terminal hasta en el 10% de los pacientes sometidos a dialisis [2-4].
Actualidad de la enfermedad renal poliquistica
"ADPKD is the most common inherited and the fourth most common overall cause of kidney failure worldwide," said lead author Vicente Torres, M.D., Ph.D., Mayo Clinic nephrologist.
Promising therapy for inherited form of kidney disease identified
Early research reveals that certain signals within cells may contribute to cyst growth in ADPKD patients.
Post-transplant immunosuppressive drug may also help patients with a common genetic kidney disease
Family history also plays a role in the incidence of intracranial aneurysms and SAH in patients with ADPKD. Between 18% and 22% of ADPKD patients with intracranial aneurysm have a family history positive for aneurysm.[4]
Epidemiology of Intracranial Aneurysm and Subarachnoid Hemorrhage
Among them, ADPKD, which is a hereditary and intractable disease, calls for earlier diagnosis, prevention of deterioration of the disease, and broader awareness of it among society and the health professions.
Otsuka Pharmaceutical Co., Ltd. - Otsuka and Japan Kidney Association to Collaborative on Autosomal Dominant Polycystic Kidney Disease -- 22/5/2019
Her two children were also evaluated for ADPKD, and they both did not have any evidence of disease at present, and hence they are kept under followup.
AN INTERESTING CASE OF ABDOMINAL MASS
This variable anatomy presents an added challenge to that of operating on large ADPKD kidneys.
Pure laparoscopic unilateral nephrectomy for a patient with a polycystic horseshoe kidney
Kidney infection in ADPKD includes acute pyelonephritis and/or cyst infection (CI) (3).
Cyst infection in hospital-admitted autosomal dominant polycystic kidney disease patients is predominantly multifocal and associated with kidney and liver volume
The most common form of this condition is called autosomal dominant polycystic kidney disease (ADPKD), a condition passed on to children from one parent affected with the disease that is found in 600,000 people in the United States alone.
Single gene that controls growth of many forms of polycystic disease found
Current knowledge on cyst initiation and development mainly comes from investigations on autosomal dominant polycystic kidney disease (ADPKD), in which cystic pathology is believed to be the result of abnormal cell proliferation and deregulated apoptosis, increased secretion of fluids into the tubular lumen, irregular cell-matrix interactions, and defective cellular polarity.
Cystic diseases of the kidney: molecular biology and genetics
Autosomal dominant polycystic kidney disease (ADPKD) affects approximately 500,000 people in the United States and is the most frequent genetic cause of renal failure in adults, accounting for 10% of patients on dialysis in the U.S.
Autosomal dominant polycystic kidney disease: a case study
The autosomal dominant polycystic kydney disease (ADPKD) is the most common inherited form of an autosomal dominant disease.
A tutorial in genetic epidemiology and some considerations in statistical modeling

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