ADP ribosylation

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ADP ri·bo·syl·a·tion

covalent attachment of an ADP-ribosyl moiety to a macromolecule, for example, the action of diphtheria toxin.
References in periodicals archive ?
Evidence indicates that ADP-ribosylation biology underlies the pathomechanisms of cancer, neurodegenerative and metabolic disorders.
After ADP-ribosylation by CT, the AC remains in its GTP-bound state resulting in enhanced AC activity and an increased intracellular cAMP concentration.
When fully activated, as is the case after ROS exposure following TBI, PARP-1 activation and ADP-ribosylation deplete the nicotinamide adenine dinucleotide ([NAD.
We developed an ADP-ribosylation assay for enzymatically active DT.
Raci was also found to localize to the membrane compartment in response to ExoS, suggesting that Rac1 is activated following ADP-ribosylation by ExoS.
Cholera toxin-catalyzed ADP-ribosylation did not reveal Gs-like proteins in Y-organs.

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