ADP ribosylation

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ADP ri·bo·syl·a·tion

covalent attachment of an ADP-ribosyl moiety to a macromolecule, for example, the action of diphtheria toxin.
References in periodicals archive ?
In addition, the E18 residue showed PTM sites for proteolytic cleavage, carboxylation and ADP-ribosylation. Therefore, amino acid polymorphism at E18 position is likely to have impact on post translational modification process of human UTY protein.
Guo et al., "MicroRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma," Clinical Cancer Research, vol.
(4) Rendering native substances immunogenic in vivo is said to be the breakage of "immunological tolerance", the details of which have recently been extensively reviewed, where ADP-ribosylation of histone is also described as a frontier in this field.
After ADP-ribosylation by CT, the AC remains in its GTP-bound state resulting in enhanced AC activity and an increased intracellular cAMP concentration.
A quantitative analysis for the ADP-ribosylation activity of pertussis toxin: an enzymatic-HPLC coupled assay applicable to formulated whole cell and acellular pertussis vaccine products.
Polymerase chain reaction assay for diagnosis of potentially toxinogenic Corynebacterium diphtheriae strains: correlation with ADP-ribosylation activity assay.
Activation of PARP-1 stimulates poly ADP-ribosylation, which in turn leads to the formation of poly(ADP-ribose) (PAR) units that serve as protein modifying agents (Koh et al., 2005).
The ADP-ribosylation takes place on this diphthamide, resulting in inactivated eEF2 and blocked protein biosynthesis (10).
However, a shift in the mobility of Raci was detected following exposure to ExoS producing bacteria, which was confirmed by two-dimensional electrophoresis to be consistent with ADP-ribosylation. Raci was also found to localize to the membrane compartment in response to ExoS, suggesting that Rac1 is activated following ADP-ribosylation by ExoS.

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