ADNP


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ADNP

A gene on chromosome 20q13.13 which encodes a protein that is up-regulated by vasoactive intestinal peptide (VIP) and may be involved in VIP’s stimulatory effect on normal cell growth and cancer proliferation. The encoded protein contains one homeobox and 9 zinc finger domains, suggesting a role as a transcription factor in proliferation, neuroprotection and increasing viability of certain cell types by modulating p53 activity.
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References in periodicals archive ?
The second lowest RI belongs to the ADNP gene, which is essential for brain formation and correct neural development [36].
Van Dijck et al., "The transcriptional regulator ADNP links the BAF (SWI/SNF) complexes with autism," American Journal of Medical Genetics Part C: Seminars in Medical Genetics, vol.
Coe et al., "A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP," Nature Genetics, vol.
Para aquellas colonias que cambiaron su fenotipo silvestre se les realizo nuevamente la extraccion del ADNp segun los protocolos descritos, para correlacionar la perdida de algun(as) de la(s) banda(s) de ADNp con los fenotipos de resistencia observados en las cepas parentales.
Los fenotipos de susceptibilidad y bandas de ADNp presentes en las cepas estudiadas fueron analizados a traves de estadisticos descriptivos como frecuencias y reportandose la distribucion porcentual de la susceptibilidad a los diferentes farmacos ensayados en las cepas de S.
El perfil plasmidico de estas colonias mostro la permanencia de la banda de ADNp de 23,268 kpb (FIG.
The clinical-stage drug, davunetide is based on ADNP, and its therapeutic potential is focused on frontotemporal dementia, Alzheimer's disease, and cognitive impairment in schizophrenia.
The presence of the apical projection arising from the cell bodies in the ADNP suggests that this plexus may have a sensory role.