ADME


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ADME

An acronym for the 4 phases—absorption, distribution, metabolism, excretion—which describe pharmacokinetics in mammals.
References in periodicals archive ?
ADME is the abbreviation for absorption distribution, metabolism and elimination, a pharmacology and pharmacokinetics term that describes the disposition of a drug or compound inside the human body.
The exposure-ADME workflow incorporates exposure and ADME considerations for linking chemical exposure with AOP activation through the MIE.
Certain expert contract research organizations (CROs) have a wealth of ADME experience and expertise, and can adapt and tailor their services to meet the client's needs and, as these can be called upon as required, can be an effective way to control costs.
(35.) Smirnov YA, Lipatov AS, Gitelman AK, Claas ECJ, Osterhaus ADME. Prevention and treatment of bronchopneumonia in mice caused by mouse-adapted variant of avian H5N2 influenza A virus using monoclonal antibody against conserved epitope in the HA stem region.
The ADDA system is a high-speed autosampler designed for drug discovery that provides ADME discovery scientists with a fast sample delivery platform for liquid chromatography/mass spectrometry (LC/MS).
The acquisition expands Evotec's drug discovery platform and capabilities with access to Cyprotex's ADME-Tox platform and in vitro ADME screening, mechanistic and high-content toxicology screening and predictive modelling.
Pharmacokinetics (PK, also most recently termed biokinetics), i.e., the assessment of absorption, distribution, metabolism, and excretion (ADME) of chemicals (xenobiotics), has transformed our understanding of in vivo pharmacology.
When asked how he would describe current trends ADME and toxicology testing, he said:
ADME and Translational Pharmacokinetics/ Pharmacodynamics of Therapeutic proteins: Applications in Drug Discovery and Development
Meeting the demands of both the occasional and the high-throughput user, the new format helps to address many of the unmet needs for preclinical ADME screening, safety studies, and new regulatory guidelines in the United States and Europe," said Paul Brooks, Ph.D., of Sigma Life Science.
The authors report that serum PFOA concentrations predicted by linked exposure and absorption, distribution, metabolism, and excretion (ADME) models are well correlated with observed 2005-2006 human serum concentrations for C8 Health Project participants.
Its core products include the Cloe Screen(R) in vitro ADME/toxicity service, and Cloe PK(R) - a pharmacokinetics prediction system which integrates core ADME and physicochemical compound data to predict compound levels in plasma and major organs in the body.