LMNB1

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LMNB1

A gene on chromosome 5q23.2 that encodes lamin B1, a protein highly conserved in evolution that forms part of the two-dimensional matrix of proteins located next to the inner nuclear membrane. Lamins are involved in providing nuclear stability and chromatin structure, and in gene expression.

Molecular pathology
LMNB1 mutations cause autosomal dominant adult-onset leukodystrophy (ADLD).
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Method for Similarity/Dissimilarity Analysis of Protein Sequences Based on the ADLDs. According to the above analysis, we have known that the ADLDs may be useful in analyzing the differences of the inner structures of protein sequence pairs.
Generally, suppose that there are N protein sequences {[[psi].sub.1], [[psi].sub.2], ..., [[psi].sub.N]}; then while applying the ADLDs to analyze the similarity/dissimilarity of these N sequences, the similarity/dissimilarity matrix of these N sequences can be obtained through the following steps.
According to the above steps, we present an example through implementing the ADLDs to analyze the similarity/dissimilarity of 16 ND5 proteins (illustrated in Table 5) while letting [delta] - 3 and illustrate the results of similarity/dissimilarity matrix in Table 6.
That is to say, our ADLDs based method can be utilized as an effective way to analyze the similarities/dissimilarities of protein sequences.
The Phylogenetic Tree of the Protein Sequences Based on the ADLDs. A phylogenetic tree is a diagram that is used to represent the evolutionary relationships of organisms that are thought to have a common ancestry, and it is a commonly used tool for researchers in some fields to help them analyze the clustering of different species.
To further validate the performance of our ADLDs based method, we applied our method to analyze the similarity/dissimilarity of another group of proteins including 29 spike proteins of coronavirus and compared our method with the method proposed by Wen and Zhang [17] based on the above given 16 ND5 proteins and the following 29 spike proteins, respectively.
From observing Figure 4, it is easy to know that the 29 spike proteins of coronavirus can be perfectly classified into the above four classes by our ADLDs based method.
But, on the contrary, the phylogenetic trees obtained by our ADLDs based method are not only quite reasonable but also consistent with the known facts of evolution to some degree.
The Analysis of Intuition and Visuality of the ADLDs. In Section 2.6, we have stated that the ADLDs of protein sequence pairs are intuitional and visual.
From these similar/dissimilar pairs, we will choose three pairs including (human, gorilla), (human, opossum), and (human, gallus) as examples to further show the intuition and visuality of the ADLDs of these three protein sequence pairs.
And, through statistic, we can know that the actual total lengths of all of the SFs in the ADLDs of these three protein sequence pairs (human, gorilla), (human, opossum), and (human, gallus) are 556, 288, and 248, respectively.
Hence, from the above descriptions, we can know that the ADLDs obtained by our newly proposed method are quite visual and intuitional and maybe a powerful and effective tool for visual comparison of protein sequences and numerical sequences in other research fields.