ADIPOQ


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Related to ADIPOQ: Adiponectin, Resistin

ADIPOQ

The gene on chromosome 3q27 which encodes adiponectin, a key adipokine involved in the control of fat metabolism and insulin sensitivity. ADIPOQ is only expressed only in adipose tissue.
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To validate and confirm these findings in a prospective setting, we conducted an extended investigation to examine the possible association of 5 variations [-11377C>G (rs266729), -10066G>A (rsl82052), -3971A>G (rs822396), +45T>G (rs2241766), and +276G>T (rs1501299)] in ADIPOQ with risk of incident MI and ischemic stroke in participants drawn from the Physicians Health Study (PHS) cohort.
In the present nested case-control investigation, we found no evidence for an association of the tested ADIPOQ gene variations/haplotypes with risk of incident MI.
ADIPOQ gene variations have also been associated with differential plasma adiponectin concentrations (11-18); in particular, the +45T>G and +276G>T gene variants and haplotypes carrying these specific variants were recently shown to be associated with decreased plasma adiponectin concentrations (30, 31), suggesting a functional involvement of the ADIPOQ gene in inflammatory responses via altered transcriptional activity.
Several studies have found associations of ADIPOQ variations with risk of cardiovascular disease in persons without (13) as well as with diabetes (14,19, 20), but none have evaluated associations with actual atherothrombotic events in a nondiabetic population.
Thus, the functionality of ADIPOQ gene variants and the pathophysiologic consequences of their altered transcriptional activity remain elusive.