ADH6

ADH6

A gene on chromosome 4q23 that encodes class-V alcohol dehydrogenase, which like other alcohol dehydrogenases metabolises various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. It is expressed in the stomach and liver, and has a glucocorticoid response element upstream of its 5' UTR.
References in periodicals archive ?
To date, seven different ADH genes--ADH1A, ADH IB, ADH 1C, ADH4, ADH5, ADH6, and ADH7--have been identified clustered together on the long arm of chromosome 4 (Edenberg 2007).
ADH1, ADH2, ADH3, ADH4, ADH6, ADH5, ADH7 and ADH8 primers, Saccharomyces sppstrains used on wine production identifying variations at DNA level among the yeasts (Raton, 2004).
This cluster contains, in addition to the genes encoding ADH class I isozymes, the genes ADH4, ADHS, ADH6, and ADHI, which encode other ADH enzymes.
More recent evidence suggests that genetic variants in the ADHIA, ADHIB, ADHI C ADHS, ADH6, and ADH7 genes are associated with illicit drug dependence and that this association is not purely attributable to co-morbid alcohol dependence (Luo et al.
For example, several studies found other variations in and near the ADH1B gene, as well as in or near the ADH4, ADH1C, ADH5, ADH6, and ADH7 genes that affect risk for alcoholism or the level of alcohol consumption (see the article by Hurley and Edenberg, pp.
ADH6 mRNA is present in fetal and adult liver, but the enzyme has not been isolated from tissue and little is known about it.
Although the ADH6 gene has been identified, there are as yet no physiological data on the functions of the ADH6 enzyme.